KLF1 regulatory networks in health and disease

我们将研究主控基因克虏伯样因子1如何协调红细胞的产生。我们将使用遗传和细胞生物学方法来确定该因子如何以细胞特定的方式解释基因组蓝图。我们还将确定KLF1突变如何导致人类疾病，如先天性促红细胞增生性贫血和胎儿血红蛋白的遗传性持久性。这对成人镰状细胞病HbF的再激活具有启示意义。

We will investigate how the master control gene, Kruppel-like factor 1, orchestrates production of red blood cells. We will use genetic and cell biology approaches to determine exactly how this factor interprets the genome blueprint in a cell specific manner. We will also determine how mutations in KLF1 cause human diseases such as congenital dyserythropoietic anemia and hereditary persistence of fetal haemoglobin. This has implications for reactivation of HbF in adults with sickle cell disease.