Klf5 function in normal and leukaemic haemopoiesis

急性髓系白血病(AML)是一种对儿童和成人都有影响的破坏性疾病。迫切需要针对特定基因异常的新治疗方法。我们已经确定KLF5是一个可能控制血细胞成熟的基因。在AML患者样本中，我们发现KLF5基因的变化可能抑制其活性，并有助于白血病的形成。这些白血病可能是用名为甲基转移酶抑制剂的新药治疗的很好的候选药物。

Acute Myeloid Leukaemia (AML) is a devastating disease that affects both children and adults. New treatments that target particular genetic abnormalities are urgently needed. We have identified KLF5 as a gene that may control blood cell maturation. In AML patient samples we have found alterations of the KLF5 gene that may suppress its activity and contribute to the formation of leukaemia. These leukaemias may be good candidates for treatment with new drugs called methyltransferase inhibitors.