PDT Physics Core

摘要 核心A： 物理核心负责为体内和体外的光提供和维护PDT激光光源 光输送系统的质量保证和绝对光剂量测定的剂量测定 可追溯到NIST的标准。它将有用的技术应用于常规临床应用。 物理核心负责为所有项目提供激光支持和体内光剂量学。它起作用了 与项目1合作开发治疗胸膜疾病的人体临床试验。核心支持维护 位于斯米洛翻译研究中心(SCTR8W)8楼的激光器的使用 这将用于项目2、3和4中的细胞和小鼠PDT实验。 照明将通过动物/病理中心的服务进行，并由 物理核心根据需要。此外，物理核心将进行每年一次的剂量测量现场访问 在罗斯韦尔公园癌症研究所(RPCI)进行校准，并将远程执行光的季度审查 通过电子邮件提交的RPCI剂量学数据。 物理核心将开发技术，以改进人体临床试验的PDT剂量学，以实现更好的效果 光通量分布的均匀性。组织光学性质、血流、增敏剂的测定 个体患者的分布和组织氧合可能被证明在提供个性化的 制定治疗计划，从而改善癌症治疗。 物理核心的主要组成部分可概括为：1)提供维护和 用于光动力治疗的激光和光源的操作；2)体内和体外光剂量学的性能；3) 绝对光剂量学测量；4)支持RPCI的光剂量学；5)执行显式PDT 组织光学性质、药物浓度和组织氧合前、中、后的剂量测定 光动力疗法。

Abstract Core A: The Physics Core is responsible for providing and maintaining PDT laser sources, for in vivo and ex vivo light dosimetry, for quality assurance of light delivery systems, and for establishment of absolute light dosimetry standards traceable to NIST. It implements useful technologies to routine clinical application. The Physics Core is responsible for providing laser support and in vivo light dosimetry for all projects. It works with Project 1 to develop human clinical trials for treatment of pleural disease. The core supports maintenance and operation of the lasers housed in the 8th floor of the Smilow Center for Translational Research (SCTR 8W) that will be used for the cell and mouse PDT experiments included in Projects 2, 3 and 4. All of these illuminations will be performed through the services of the Animal/Pathology Core with assistance from the Physics Core as needed. In addition, the Physics Core will perform an annual on-site visit for dosimetry calibration at Roswell Park Cancer Institute (RPCI) and will remotely perform quarterly reviews of the light dosimetry data from RPCI via email submission. The Physics Core will develop techniques to improve PDT dosimetry for human clinical trials to achieve better uniformity of light fluence distribution. Determination of tissue optical properties, blood flow, sensitizer distribution, and tissue oxygenation for individual patients may prove to be important in providing individualized treatment planning and thus improving cancer treatment. The major components of the Physics Core can be summarized as follows: 1) to provide maintenance and operation of laser and light sources for PDT; 2) performance of in vivo and ex vivo light dosimetry; 3) measurement of absolute light dosimetry; 4) support for light dosimetry at RPCI and 5) to perform explicit PDT dosimetry for tissue optical properties, drug concentration, and tissue oxygenation before, during, and after PDT.