Ultra-high Performance MicroSPECT/CT system

 描述(由申请人提供)：本共享仪器建议购买混合多准直器MicroSPECT/CT成像系统(Milabs MicroSPECT4CT)，目标是在小动物中进行高分辨率、高灵敏度的放射性核素靶向分子成像。拟议的最先进的SPECT/CT成像系统将支持耶鲁大学医学院目前由NIH资助的多名研究人员的需求，这些研究人员来自医学系、诊断放射学系、实验室医学系和病理学系。用户小组参与了各种项目，这些项目将利用相机的多种功能，包括拟议的四个不同的准直器。这4种不同的准直器在大鼠和小鼠模型中都提供了高分辨率和高灵敏度的选项。此外，除了列表模式数据外，该系统还可以获取心脏和呼吸门控图像，以实现高灵敏度的动态成像。SPECT和CT组合单元提供功能性SPECT图像与高分辨率和解剖CT图像的内在配准，以实现图像量化的目的。CT图像可以校正与SPECT成像相关的衰减和部分体积误差，从而能够对放射性示踪剂摄取进行绝对量化。这些系统功能对我们的项目至关重要，在我们的项目中，我们有一系列由NIH资助的项目，从评估小鼠心房到测量大鼠心肌或肺的动态血流。为了获得FDA对IND的批准，该系统可用于评估体内靶向放射性示踪剂的生物分布、特定器官摄取和清除动力学。SPECT和CT数据的合并也将有助于MIRD计算吸收辐射剂量。随着我们迈向多模式成像项目，SPECT和CT数据的配准也将促进SPECT图像与独立获取的PET和MR图像的关联。因此，拟议的系统将满足这一共享仪器赠款研究人员的所有需求，允许在小动物中进行高分辨率、高灵敏度成像，并绝对量化放射性示踪剂摄取。

 DESCRIPTION (provided by applicant): This shared instrument proposal is for purchase of a hybrid multi-collimator microSPECT/CT imaging system (MILabs MicroSPECT4CT), with a goal of high resolution, high sensitivity radionuclide targeted molecular imaging in small animals. The proposed state-of-the-art SPECT/CT imaging system will support the needs of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Medicine, Diagnostic Radiology, Laboratory Medicine, and Pathology. The user group worked on a variety of projects, which would utilize multiple features of the camera including the proposed four different collimators. The 4 different collimators provide options for high resolutio and high sensitivity in both rat and moues models. Additionally, this system can acquire cardiac and respiratory gated images in addition to list mode data for high sensitivity dynamic imaging. The combined SPECT and CT unit provides inherent registration of functional SPECT images with high resolution and anatomical CT images for the purpose of image quantification. The CT images allow for correction of attenuation and partial volume errors associated with SPECT imaging, permitting absolute quantification of radiotracer uptake. These system features are critical for our program wherein we have a spectrum of NIH funded programs from assessment of mouse atria to dynamic flow measurements in the rat myocardium or lungs. To obtain FDA approval for an IND, this system can be used to evaluate in vivo targeted radiotracers for biodistribution, specific organ uptake and clearance kinetics. The merging of SPECT and CT data will also facilitate MIRD calculations for estimation of absorbed radiation dose. The registration of SPECT and CT data will also facilitate correlation of SPECT images with independently acquired PET and MR images as we moved towards multi-modality imaging projects. Thus, the proposed system would meet all of the needs of the investigators of this shared instrumentation grant, allowing for high resolution, high sensitivity imaging in small animals and absolute quantification of radiotracer uptake.