Multidisciplinary Subspecialty Pathology Research Fellowship Program

描述(申请人提供)：在后基因组时代，关于包括人类在内的各种生物的生物医学数据的急剧扩大，揭示了生物系统的巨大复杂性，并增加了我们对许多疾病过程的了解。这在肿瘤疾病中尤其明显，在这些疾病中，基因组、表观基因组、转录组和蛋白质组规模的分子技术揭示了独特的分子途径及其网络，提供了关于治疗策略和临床结果的重要信息。这反过来又影响了包括病理学在内的许多医学学科的执业标准。癌症医学中新发展的个性化和靶向治疗的概念增加并改变了病理学作为临床学科的传统角色。通过复杂的技术手段对肿瘤进行不断扩大的分子检测，需要重新设计传统的显微病理学服务。这项T32提案旨在提供资源，通过基于实验室的研究培训来培训新一代病理学家，这些培训将补充目前由德克萨斯大学MD安德森癌症中心病理学系认可的临床研究员项目的研究生医学教育认证委员会。该计划的目标是培养能够将诊断病理学的传统作用与研究分子方法相结合的下一代医生/科学家病理学家。为了实现这一目标，一个专注于两年的研究计划将把受训者与经验丰富的教育工作者配对，他们也是有成就的翻译研究人员。受训者将在他们导师的实验室工作，接受当今翻译研究所需的实验室方法、流程和团队导向方面的培训。该项目的毕业生将完成旨在通过以患者为导向的个性化治疗来改善患者护理的研究项目，最后向同行评议的期刊提交一份手稿。德克萨斯大学MD安德森癌症中心的课程和广泛的教育机会将补充实验室研究培训。与专科临床培训相结合，该计划将培养出非常合格的学术、研究型病理学家，他们本身就可以成为独立的研究人员和未来的学术导师。

DESCRIPTION (provided by applicant): Dramatic expansion of biomedical data in the post-genomic era on various organisms, including humans, has disclosed the enormous complexity of biological systems and increased our knowledge of many disease processes. This is particularly evident in reference to neoplastic disorders where molecular technologies on a genome, epigenome, transcriptome and proteomic scale have disclosed unique molecular pathways and their networks that provide significant information concerning therapeutic strategies and clinical outcomes. This in turn has affected the standard of practice of many medical disciplines including pathology. The newly developed concept of personalized and targeted therapies in cancer medicine increased and changed the traditional roles of pathology as a clinical discipline. The expanding molecular testing of tumors, with complex technologic approaches, requires a redesign of the conventional microscopic pathology services. This T32 proposal is intended to provide resources to train a new generation of pathologists via laboratory-based research training that will complement the current Accreditation Council for Graduate Medical Education-accredited clinical fellowship programs of the Department of Pathology at The University of Texas MD Anderson Cancer Center. The goal of this program is to train the next generation of physician/scientist pathologists capable of combining the conventional role of diagnostic pathology with investigative molecular approaches. To accomplish this goal, a focused 2-year research program will pair trainees with experienced educators who are also accomplished translational researchers. The trainees will work in their mentors' laboratories training in laboratory methods, processes, and team orientation needed in today's translational research. The graduates of this program will complete research projects aimed at improving patient care with patient-directed personalized treatment, concluding with the submission of a manuscript to a peer-reviewed journal. Coursework and a wide range of educational opportunities at The University of Texas MD Anderson Cancer Center will complement the laboratory research training. Combined with subspecialty clinical training, this program will produce extremely well-qualified academic, research-oriented pathologists who can, by themselves, be independent researchers and future academic mentors.