Translational Research Activities in Neuropsychiatry (TRAIN)

描述（由申请人提供）：神经科学、遗传学和对行为生物学的理解的进步为理解和治疗精神疾病提供了一个深刻的进步机会。为了利用这些进步，下一代精神病学研究人员需要集中训练，将转化研究与临床/行为训练相结合。虽然在该领域存在严重缺乏正在接受培训的内科科学家的担忧（Yager等人，2004年；Fenton等人，2004年；“精神病学的身份危机”2012年），但也有理由乐观，因为医学院的医学博士/博士毕业生申请精神病学住院医师的人数有所增加。在过去的几十年里，联邦政府对精神科的研究资金大幅增加，然而，接受过充分研究培训、投入研究时间和在资助资助中担任领导角色（如首席研究员）的精神科医生的比例远远落后于其他医学领域（Kupfer et al., 2002）。为了满足这些需求，我们请求支持一个转化临床研究培训计划的发展。临床神经科学转化研究活动（TRAIN）项目旨在为精神病学住院医师提供特殊的培训和指导，其明确目标是培养精神病学临床和转化研究人员，他们将继续成为独立的内科科学家。该计划将重点关注潜在遗传学和神经生物学的中断之间的关系，以及它们如何与NIMH研究领域标准（RDoC）框架中的适应性行为相关。该项目将为精神病学住院医师提供培训，并由全国公认的精神病学转化研究人员提供指导。该项目包括德克萨斯大学西南分校的教师导师和活跃的研究项目，以及其他机构的全国知名研究人员的会议和指导。该项目还旨在吸引正在接受培训的学生，招募最优秀的人才成为临床研究人员。

DESCRIPTION (provided by applicant): Advances in neuroscience, genetics, and the understanding of the biology of behavior have provided an opportunity to make profound advancements in understanding and treating mental illnesses. In order to take advantage of these advances, the next generation of researchers in psychiatry will need focused training that integrates translational research with clinical/behavioral training. While there is concern in the field of profound shortage of physician-scientists being trained (Yager et al., 2004; Fenton et al. 2004; "Psychiatry's Identity Crisis" 2012), there is also reason for optimism, in that the number of MD/PhD medical school graduates applying for psychiatric residencies has increased. Federal research monies have increased substantially to psychiatry departments over the last few decades, and yet, the percentage of psychiatrists with adequate research training, dedicated research time, and leadership roles (e.g., Principal Investigator) on funded grants lags well behind other areas of medicine (Kupfer et al., 2002). In order to address these needs, we are requesting support for the development of a translational clinical research training program. The Translational Research Activities In Clinical Neuroscience (TRAIN) program is designed to provide exceptional training and mentoring to psychiatry residents with the express goal of generating clinical and translational researchers in psychiatry who will go on to become independent physician-scientists. This program will focus on the relationship between disruptions in underlying genetics and neurobiology and how they relate to adaptive behavior, as in the NIMH Research Domain Criteria (RDoC) framework. This program will provide psychiatry residents training and mentorship from nationally recognized translational researchers in psychiatry. The program includes faculty mentors at UT Southwestern with active research programs, as well as meetings and instruction by nationally recognized researchers at other institutions. The program is also designed to reach out to students in training to recruit th best minds to become clinical researchers.