Molecular Mechanisms of Disease

 描述（由申请人提供）：内布拉斯加大学林肯分校建议建立疾病的分子机制（MMoD）博士前培训计划，以提供以分子相互作用和化学转化为中心的生物医学研究的创新培训和职业发展。该计划弥合了NIH细胞，生物化学和分子科学培训重点的九个州的差距。该计划的目标是培养杰出的新科学家，他们在合作的多学科团队中工作，使用定量方法研究疾病机制，最终产生切实的预防和治疗策略。为了实现这一目标，该计划将招募高质量，积极的博士前学员，对人类疾病的根本原因有浓厚的兴趣，并让他们参与指导，尖端研究。具体目标是：（1）提供严格的课程和创新，合作研究的机会，每年为16名博士前学员（8个NIH支持和8个机构支持），成为人类疾病的机制研究的专家;（2）培养一个互动的培训环境，强调发展专业网络，团队，领导力，书面和口头沟通方面的杰出技能;（3）支持导师在机制性疾病研究重点的四个领域的合作培训工作：分子信号，代谢完整性，氧化应激和疾病微环境。NIH的支持将跨越为期两年的五年计划，为具有本科实验室经验的学员提供为期两年的培训，并在T32培训期之前提供一年的研究生课程。新学员的选择将是竞争性的，基于良好的学术记录，研究进展和潜力，以及创新论文研究的学科界限的原创合作建议。MMoD指导团队跨越七个部门和三个学院，包括28名教师，所有在生物医学研究资金和研究生指导的强大历史。学员将在第一年完成四个研究轮换，然后选择代表四个重点领域之一的教师导师。学员将采取灵活的核心课程：代谢功能和功能障碍，从批准的核心一个定量生物学课程，并从批准的核心两个大分子课程。通过这些课程，他们将接受正式的培训，在granitarian，科学写作，和研究 期刊文章介绍。他们还将获得独特的创业学习和教学机会，并将组织一次以该计划外部咨询委员会会议为中心的年度研讨会。MMoD计划将提供一个框架，使学员能够组装广泛的知识基础;积极寻求研究合作;产生原始发表研究的杰出记录;并开发演示文稿，提案写作和领导技能，使他们成为未来卓越的独立研究人员，专注于疾病进展的机制。

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln proposes to establish the Molecular Mechanisms of Disease (MMoD) predoctoral training program to provide innovative training and career development in biomedical research centered on molecular interactions and chemical transformations. The program bridges a nine-state gap in the NIH training focus of Cellular, Biochemical, and Molecular Sciences. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program will recruit high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. The specific aims are to: (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for sixteen predoctoral trainees per year (eight NIH-supported and eight institutionally supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive training environment that emphasizes development of outstanding skills in professional networking, grantsmanship, leadership, and written and oral communication; (3) Support collaborative training efforts of mentors in four areas of mechanistic disease research emphasis: molecular signaling, metabolic integrity, oxidative stress, and disease microenvironment. NIH support will span two years of a five-year program for trainees with undergraduate laboratory experience and one year of graduate-level coursework prior to the T32 training period. Selection of new trainees will be competitive, based on strong academic record, research progress and potential, and an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. The MMoD mentoring team spans seven departments and three colleges and includes 28 faculty members, all with strong histories in biomedical research funding and graduate student mentoring. Trainees will complete four research rotations in year 1 before choosing a faculty mentor representing one of the four emphasis areas. Trainees will take a flexible core curriculum: Metabolic Function and Dysfunction, one Quantitative Biology course from an approved core, and two Macromolecules courses from an approved core. Through these courses, they will receive formal training in grantsmanship, scientific writing, and research and journal article presentations. They will also be provided with unique entrepreneurial learning and teaching opportunities and will organize an annual symposium centered on the meeting of the program's external advisory committee. The MMoD program will provide a framework that enables trainees to assemble a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that will position them for future excellence as independent researchers focused on mechanisms of disease progression.