无特定病原体恒河猴群体（U42）的建立-猫眼课题宝

无特定病原体恒河猴群体（U42）的建立

批准号：

9037076

负责人：

Gregory Brion Timmel

金额：

$35.79万

依托单位：

OREGON HEALTH & SCIENCE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-01-01 至 2016-12-31

来源：

https://reporter.nih.gov/project-details/9037076

关键词：

AIDS Vaccines Acquired Immunodeficiency Syndrome Address Adult Affect Animals Antiviral Agents Bioinformatics Biological Assay Biomedical Research Breeding Cause of Death Cercopithecine Herpesvirus 1 Complex Analysis Disease Employment Ensure Female Funding Future Genetic Genetic Variation Genotype Grant HIV HIV therapy HIV vaccine HIV-1 Health Housing Human Immune system Infection Infectious Agent Label Life Macaca Macaca mulatta Major Histocompatibility Complex Modeling National Center for Research Resources Oregon Pathogenesis Population Primate Lentiviruses Primates Principal Investigator Production Protein Microchips Proteins Public Health Reporting Request for Applications Research Research Infrastructure Resource Informatics Resources Retroviridae SIV T-Cell Leukemia Target Populations Technology Testing Time United States Public Health Service Vaccine Research Vaccines Viral Virus aged animal model development base cost data integration design genetic profiling germ free condition health organization innovation killings leukemia virus next generation nonhuman primate novel offspring pandemic disease pathogen programs screening simian human immunodeficiency virus tool tv watching vaccine development vaccine efficacy

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中文摘要

翻译

描述（由申请人提供）：安全有效的疫苗仍然是控制人类免疫缺陷病毒（HIV）大流行的最大希望。由于源自印度的恒河猴的免疫系统与人类相似，疫苗的开发严重依赖于SIV和SHIV恒河猴模型。与艾滋病有关的研究对印度恒河猴的需求仍然超过了可用性。有效的国内育种计划成功地生产出特征良好的动物，提高了它们在生物医学研究中的应用，并为目前用于艾滋病疫苗和发病机制研究的印度恒河猴短缺提供了最佳的长期解决方案，并确保了未来的可用性。本提案的目的是继续支持和描述在过去十年赠款期间建立的特定无病原体印度恒河猴艾滋病研究群体资源。

英文摘要

DESCRIPTION (provided by applicant): A safe and effective vaccine remains the best hope of controlling the human immunodeficiency virus (HIV) pandemic. Because of the similarity of the immune system of the Indian-origin rhesus macaques and humans, vaccine development is heavily dependent on the SIV and SHIV macaque models. The need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Efficient domestic breeding programs managed to produce well characterized animals that enhance their use in biomedical research and offer the best long term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies and to insure future availability. The purposes of this proposal are to continue to support and characterize the specific pathogen-free Indian rhesus AIDS Research Colony resource that was established in the past ten-year grant period.

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