ECHO Coordinating Center

摘要 关于遗传和环境因素如何相互作用影响儿童健康结果，人们知之甚少。至 解决这些知识差距，环境对儿童健康结果的影响(ECHO)计划 承诺利用现有的儿科队列来测试环境暴露如何影响的新假设 儿科健康。杜克临床研究所(DCRI)建议作为ECHO协调机构 中心(ECHO CC)为管理、指导和整体提供组织框架 协调所有常见的回声活动。DCRI处于独特的地位，可以领导这一雄心勃勃的倡议。 作为世界上最大的学术研究机构，DCRI管理着近30个活跃的网络和 行政协调中心拨款，并已成为儿科临床研究的领导者。DCRI 将利用其在更大的儿科研究社区的广泛联系和网络，以及建立的 与主要大学和行业合作伙伴的关系，以支持在这一服务不足的人群中的研究。 DCRI的企业创造的规模经济允许使用常见的网络方法 职能和能力，当不可避免的问题和加速的时间表时，能够带来额外的专业知识 站起来。ECHO CC的总体目标是高效地管理ECHO内的协作研究 基础设施，以更好地了解环境暴露对儿童健康结果的影响。至 为了实现这一愿景，ECHO CC将建立三个组件，以开发和实施创新 在ECHO内部设计和进行研究的战略：(1)指导委员会支持 该构成部分将协调并为回声指导和执行的所有活动提供后勤支持 委员会，外部科学委员会，NIH ECHO团队，ECHO队列，ECHO核心，数据分析中心， 和生物仓库；(2)科学重点领域构成部分将协调共同研究活动 在四个回声科学焦点区域中，通过开发回声范围和特定焦点区域协议， 程序和研究文件，以促进统一每个科学重点领域的具体成果； 以及(3)机会和基础设施基金(OIF)部分将向ECHO调查人员分配资金 推广新项目、新工具、新技术，确保项目顺利完成。 监督所有这三个组件的将是ECHO CC管理组件。ECHO CC 目标将使用DCRI内已建立的基础设施来实现，并将进行定制以满足变量 回声队列、指导委员会和调查人员的需求。使用最高的研究标准，我们的 团队将实现NIH在管理这一至关重要的合作努力中设定的目标。

ABSTRACT Little is known about how genetic and environmental factors interact to affect child health outcomes. To address these knowledge gaps, the Environmental Influences on Child Health Outcomes (ECHO) program promises to leverage extant pediatric cohorts to test new hypotheses of how environmental exposures impact pediatric health. The Duke Clinical Research Institute (DCRI) proposes to serve as the ECHO Coordinating Center (ECHO CC) to provide the organizational framework for the management, direction, and overall coordination of all common ECHO activities. The DCRI is uniquely positioned to lead this ambitious initiative. As the world’s largest academic research organization, the DCRI manages nearly 30 active network and administrative coordinating center grants and has emerged as a leader in pediatric clinical research. The DCRI will leverage its broad contacts and networks in the larger pediatric research community, as well as established relationships with key university and industry collaborators, to support research in this underserved population. The economy of scale created by DCRI’s enterprise allows the use of common approaches to network functions and the ability to bring extra expertise to bear when inevitable problems and accelerated timelines arise. The overall goal of the ECHO CC is to efficiently manage collaborative research within the ECHO infrastructure to better understand the impact of environmental exposures on health outcomes in children. To achieve this vision, the ECHO CC will establish three components that will develop and implement innovative strategies across the design and conduct of research within ECHO: (1) the Steering Committee Support Component will coordinate and provide logistical support for all activities of the ECHO Steering and Executive Committees, External Scientific Board, NIH ECHO Team, ECHO cohorts, ECHO Cores, Data Analysis Center, and biorepositories; (2) the Scientific Focus Area Component will coordinate common research activities among the four ECHO scientific focus areas by developing ECHO-wide and focus area–specific protocols, procedures, and study documents to facilitate harmonization of outcomes specific to each scientific focus area; and (3) the Opportunities and Infrastructure Fund (OIF) Component will distribute funds to ECHO investigators to promote new projects, tools, and technologies and ensure successful completion of their projects. Overseeing all three of these components will be the ECHO CC Administrative Component. The ECHO CC goals will be met using established infrastructure within the DCRI and will be customized to meet the variable needs of the ECHO Cohorts, Steering Committee, and investigators. Using the highest research standards, our team will accomplish the goals set out by the NIH in managing this critically important collaborative effort.