Lentiviral infection: intracellular immunity and viral evasion

我是一名生物化学家，专注于回答这个问题：为什么人类容易感染艾滋病毒，而某些猴子却有抵抗力？据了解，这些猴子已经进化出可以靶向和摧毁病毒的蛋白质，但相当于人类的蛋白质对艾滋病毒无效。我打算比较猴子和人类的蛋白质，以了解猴子如何破坏病毒，以及为什么人类的蛋白质有缺陷。这些研究将为下一代艾滋病毒治疗提供信息。

I am a biochemist focused on answering the question: why is it that humans are susceptible to HIV infection, while certain monkeys are resistant? It is known that these monkeys have evolved proteins which can target and destroy the virus, but the equivalent human proteins don’t work against HIV. I intend to compare the monkey and human proteins to understand how the monkeys destroy the virus and why the human protein is defective. These studies will inform the next generation of HIV treatment.