Training in Cell Signaling and Lung Pathobiology

描述（由申请人提供）：本续期申请要求继续支持南阿拉巴马大学医学院肺生物学中心的“细胞信号传导和肺部病理生物学”博士前/短期培训项目。在第一轮资助（2004-2009）中，我们的博士前培训项目逐渐成熟，我们在第二轮资助（2009-2014）中增加了短期培训，以支持暑期研究经历。鉴于我们在培训方面的成功，在这次续签申请中，我们要求继续支持博士预科实习生（6个名额）和短期暑期研究的医科学生实习生（4个名额）。培训的研究领域包括肺动脉高压中肺血管收缩和血管重构的机制，血管和气道平滑肌生物学，肺内皮屏障功能的调节，急性肺损伤，氧化应激中的线粒体功能和信号，以及气道上皮和血管内皮功能中离子通道的参与。我们的项目仍然是美国南部仅有的三个提供肺研究博士前培训的项目之一，将由dr。玛丽·汤斯利和特洛伊·史蒂文斯，与内部咨询委员会协商，并由杰出的外部顾问进行年度审查。培训计划的整体结构是基于NIH和其他国家科学领导小组对广泛、跨学科培训的强烈强调。我们博士前培训项目的基础设施由基础医学博士项目的跨学科核心课程提供。博士前研修生将由T32资助2-3年。这些受训者致力于肺部生物学的研究，从项目教师中确定一名导师，并完成信号学、生物统计学/实验设计和肺部生物学/病理生物学等严格的教学高级课程。除了正式的学术课程外，博士预科学员还将参加研讨会和研究进展杂志俱乐部，以及由肺生物学中心组织的优秀职业生存技能培训。短期实习生进入一个长期组织良好的医学院学生暑期研究项目。这些受训者将完成一个为期10周的研究项目，重点是肺生物学/病理生物学。夏季培训包括必修的系列研讨会。我们的培训项目得益于25位资金充足、高度合作、全国认可的来自医学院五个系的教师的研究和指导专业知识

DESCRIPTION (provided by applicant): This renewal application requests continued support for the predoctoral/short-term training program in "Cell signaling and lung pathobiology" based in the Center for Lung Biology at the University of South Alabama College of Medicine. As the predoctoral component of our training program matured through the first cycle of funding (2004-2009), we added short-term training in the second cycle (2009-2014) to support summer research experiences. Given our success with training, in this renewal application we request continued support for both predoctoral trainees (6 slots) and medical student trainees in short term summer research (4 slots). Research areas for training include mechanisms underlying pulmonary vasoconstriction and vascular remodeling in pulmonary hypertension, vascular and airway smooth muscle biology, regulation of lung endothelial barrier function, acute lung injury, mitochondrial function and signaling in oxidant stress, and involvement of ion channels in airway epithelium and vascular endothelium function. Our program, which continues to be one of only three in the southern US providing predoctoral training in lung research, will be co- directed by Drs. Mary Townsley and Troy Stevens, in consultation with an Internal Advisory Committee and annual review by distinguished External Advisors. The overall construct of the training program is based upon the strong emphasis by NIH and other national science leadership groups on broad, interdisciplinary training. The infrastructure for our predoctoral training program is provided by an interdisciplinary core curriculum in the Basic Medical Sciences Ph.D. program. Predoctoral trainees will be supported by the T32 for 2-3 years. These trainees commit to the lung biology track, identify a mentor from among the program faculty and complete a rigorous didactic advanced curriculum in signaling, biostatistics/experimental design, and lung biology/pathobiology. In addition to formal academic coursework, predoctoral trainees will participate in seminars and the Research-in-Progress journal club, as well as outstanding career survival skills training organized by the Center for Lung Biology. Short-term trainees enter a long-standing well-organized summer research program for medical students. These trainees will complete a 10-week research project focused on lung biology/pathobiology with one of the program faculty. Summer training includes a required seminar series. Our training program benefits from the research and mentoring expertise of 25 well-funded, highly collaborative and nationally-recognized faculty from five departments in the College of Medicine, all affiliated with the Center for Lung Biology. Our goal is to provide a vibrant training environment that prepares trainees for subsequent careers in academic, industry and/or government biomedical research venues.