Administrative Core

行政核心--项目摘要 麻省理工学院/梅奥PS-OC的总体框架是了解药物之间的物理相互作用， 影响药物分布的肿瘤组织和微环境以及潜在的异质性药物 分布影响肿瘤细胞信号转导和治疗耐药的产生(药物疗效)。PS-OC将 需要一个强大的行政单位来支持和协调中心在所有站点、项目和 核心；包括日常行政和财政支助、规划和评价，正在进行 通信、试点和跨网络项目、CAC活动、参加PS-ON指导委员会 以及在项目生命周期中开发的其他举措。麻省理工学院/梅奥PS-OC将以行政为基础 在麻省理工学院科赫综合癌症研究所，NCI指定的癌症中心成立 1974年。正如过去以KI为基础的中心赠款所表明的那样，这将使我们能够利用现有的、 组织良好的行政基础设施，将为与 中心。主要负责科学项目管理和生物标本工作流程的管理 以及两个研究项目和两个共享资源核心之间的相关高内容数据将是 在梅奥诊所工作。两个小组的成员将合称为行政股(非盟)。

ADMINISTRATIVE CORE – PROJECT SUMMARY The overarching framework for this MIT/Mayo PS-OC is to understand the physical interactions between drugs, tumor tissue and the microenvironment that influence drug distribution and how potentially heterogeneous drug distribution influences tumor cell signaling and therapy resistance emergence (drug efficacy). The PS-OC will require a strong administrative unit to support and coordinate Center activities across all sites, projects and cores; including day-to-day administrative and financial support, planning and evaluation, ongoing communications, pilot and trans-network projects, CAC activities, participation in PS-ON Steering Committee and other initiatives developed over the life of the project. The MIT/Mayo PS-OC will be administratively based at MIT's Koch Institute of Integrative Cancer Research, an NCI-designated Cancer Center that was established in 1974. As demonstrated with past center grants based at the KI, this will allow us to leverage an existing, well-organized administrative infrastructure that will provide support for all business aspects related to the Center. Primary responsibility for scientific project management and managing the workflow of bio-specimens and related high-content data between the two Research Projects and two Shared Resource Cores will be based at the Mayo Clinic. Jointly the members of both teams will be referred to as the Administrative Unit (AU).