FASEB SRC on Trace Elements in Biology and Medicine

 描述（由申请人提供）： 2016年FASEB生物学和医学微量元素会议将于2016年6月5日至10日在蒙大拿州博兹曼外的大天空会议中心举行。这是最初的SRC之一，自1983年以来每两年举行一次会议，这是现在更大的会议组中的第一个，专注于生物学中的金属这一广泛主题。这个SRC与其他SRC的区别是什么（例如GRC“生物学中的金属”和“金属的细胞生物学”）的重点是铁（Fe）、铜（Cu）、锌（Zn）、锰（Mn）和硒（Se）等必需微量营养素如何促进人类与生物圈之间的生理相互作用，例如人类作为细菌和真菌病原体的宿主;金属和代谢紊乱，如糖尿病和呼吸功能障碍;金属和蛋白质聚集相关的神经变性。这种影响的广度反映在所描述的科学计划的广度以及将聚集在一起的PI及其学员。该计划将涵盖从发育生物学，遗传学和生物化学到化学，营养学和临床医学的一系列科学兴趣。会议主题将涵盖微量元素的摄取，贩运和微生物，植物和高等真核生物，包括人类的调节;微量元素在免疫和代谢紊乱中的作用;金属在神经变性。将讨论用于监测细胞中微量元素的尖端技术。这个会议系列的一个显着优势是它能够将专注于微量元素代谢的分子细节的研究科学家与研究微量元素对人类健康，营养和疾病的直接影响的科学家-临床医生联合起来;这个会议在这个词成为话题之前已经“翻译”。最后，SRC的主要目标一直是提供一个论坛，让学员和新的研究人员可以磨练他们的技能和证书，使他们能够在未来几十年接管“微量元素”领域的领导地位。我们将汇集已建立的调查人员和学员，以促进沟通，指导和合作。该系列会议的最终目标是促进对人类疾病和障碍的新治疗干预的持续发展，这些疾病和障碍至少部分反映了与微量元素代谢相关的病理生理学。

 DESCRIPTION (provided by applicant): The 2016 FASEB Conference on Trace Elements in Biology and Medicine will take place at the Big Sky Conference Center, outside of Bozeman, MT, June 5-10, 2016. This is one of the original SRCs, meeting biennially since 1983, the first of the now larger group of conferences that focus on the broad subject of metals in biology. What distinguishes this SRC from these others (e.g. GRC "Metals in Biology" and "Cell Biology of Metals") is its focus on how essential micronutrients such as iron (Fe), copper (Cu), zinc (Zn), manganese (Mn) and selenium (Se) contribute to the physiologic interaction between humans and the biosphere, e.g. humans as hosts for bacterial and fungal pathogens; metals and metabolic disorders such as diabetics and respiratory dysfunction; metals and protein aggregation-associated neurodegeneration. This breadth of impact is reflected in the breadth of the scientific program described and the PIs and their trainees who will be brought together. The program will span a range of scientific interests from developmental biology, genetics, and biochemistry, to chemistry, nutrition, and clinical medicine. Session topics will cover trace element uptake, trafficking, and regulation in microorganisms, plants, and higher eukaryotes including humans; the role of trace elements in immunity and metabolic disorders; metals in neurodegeneration. Cutting-edge techniques useful in monitoring trace elements in cells will be discussed. A notable strength of this conference series has been its ability to unite research scientists focused on the molecular details of trace element metabolism with scientist-clinicians studying the direct impact of trace elements on human health, nutrition, and disease; this Conference has been "translational" before the word became topical. Last, a primary aim of this SRC has always been to provide a forum in which trainees and new investigators can hone their skills and credentials, positioning them to take over leadership of the "Trace Elements" field in the coming decades. We will be bringing together established investigators and trainees to promote communication, mentoring, and collaborations. The ultimate goal of this conference series is to foster the ongoing development of new therapeutic interventions with respect to human diseases and disorders that, at least in part, reflect a pathophysiology related to trace element metabolism.