Phenotyping Core

表型分析核心将为ORR CC研究者提供先进的高内容、尖端的生物分子表型分析服务和数据集，涵盖通过临床表征和生物储存核心（CCBC）或其他ORR CC研究者项目获得的临床样本的遗传学、基因组学、蛋白质组学和功能性细胞生物反应。表型核心和CCBC在ORR CC内的紧密整合使得表型表征的有效性能以及临床特征与特定临床样本的分子或细胞表型的相关性成为可能。将分子或细胞表型的完整表征所需的一系列技术整合到一个核心中，使核心能够更好地协助所有ORR CC研究者根据其各自的项目需求进行有效的规划/设计、执行和数据分析。核心能够提供使用临床标本进行研究的经验，在广泛的分子和生物测定方面的必要技术专长，获得设备和资源，使尖端方法能够解决研究问题，对收集的数据进行质量控制评估，并进行数据处理，适用于表型/临床关联的高端统计建模。因此，表型核心的目标可以总结如下： 目标1：为研究人员提供实验项目设计、成本分析、实施规划和项目管理等方面的专家咨询。 目标2：提供先进的技术、集中的设备和经验丰富的人员，用于遗传、基因组、蛋白质组、免疫表型和免疫功能领域的高通量/高含量实验表型表征和生物标志物测定。 目标3：为数据质量控制、原始数据处理和更广泛的统计建模准备数据集提供指导。 目标4：评估和开发表型表征的新尖端技术。

The Phenotyping Core will provide ORDRCC investigators with access to advanced high-content, cutting-edge biomolecular phenotyping services and datasets spanning genetic, genomic, proteomic, and functional cellular bioresponses on clinical samples available through the Clinical Characterization and Biorepository Core (CCBC) or from other ORDRCC Investigator projects. The tight integration of the Phenotyping Core and the CCBC within the ORDRCC enables both the efficient performance of phenotype characterizations and correlation of the clinical characteristics with molecular or cellular phenotypes on specific clinical samples. Consolidation of the range of technologies required for the complete characterization of a molecular or cellular phenotype into a single Core allows the Core to better assist all ORDRCC investigators in the efficient planning/design, execution and data analysis as dictated by their individual project needs. The Core is able to provide experience in performing research using clinical specimens, the necessary technical expertise in a wide range of molecular and bioassays, access to equipment and resources enabling cutting-edge approaches to address research questions, quality control assessment of the data collected and data processing suitable for higher end statistical modeling of phenotype/clinical associations. Therefore, the goals of the Phenotyping Core can be summarized as follows: Goal 1: Offer expert consulting for experimental project design, cost analysis, implementation planning and project management for ORDRCC investigators. Goal 2: Provide access to advanced technology, centralized equipment and experienced personnel for high throughput/high content experimental phenotype characterization and biomarker assays in genetic, genomic, proteomic, immune phenotype and immune functional domains. Goal 3: Supply guidance on data quality control, processing of raw data, and preparation of data sets for more extensive statistical modeling. Goal 4: Assess and develop new cutting edge technologies for phenotype characterization.