Patient Oriented Research and Mentoring in Obesity and Urinary Incontinence

 描述（由申请人提供）：尿失禁（UI）和下尿路症状（LUTS）影响几乎一半的美国女性，并导致严重的痛苦、生活质量下降和日常功能严重受限。肥胖是一种美国和全球流行病，与巨大的健康和生活质量影响相关，是UI最强的独立风险因素之一，减肥是UI的有效治疗方法。然而，肥胖促进UI和LUTS的机制以及为什么减肥对女性有效或UI的机制知之甚少。该提案概述了一个为期5年的K24职业中期研究者奖在以患者为导向的研究（POR）更新申请的候选人，以扩大她的指导工作与早期职业生涯以患者为导向的研究人员，并促进多学科，转化研究范式，重点是体重和体重减轻与UI和LUTS的关联。除了指导计划外，该提案还概述了具体目标，通过检查体重和体重减轻对女性UI/LUTS的影响，炎症，体力活动，压力和身体习惯在肥胖和UI/LUTS之间的关系中的可能作用，继续推进我们对UI，LUTS和肥胖症之间关系的理解。并促进治疗和预防这些病症的新方法的转化发展。这项以患者为导向的研究和指导提案的目标将通过有效利用现有资源来实现，包括正在进行的NIH资助的临床试验、综合数据集和富有成效的研究合作。候选人的长期目标是成为UI研究的领导者，为我们对UI和LUTS的治疗和预防的理解和方法做出实质性贡献，并指导对女性尿失禁的流行病学和治疗感兴趣的“下一代”调查人员。阐明女性肥胖与UI和LUTS之间的关联机制将促进治疗和预防这些疾病的新方法的转化发展。候选人的优势包括她在研究方法，研究生产力和NIH资助的历史，以及指导初级学员的成功记录的正式培训。该机构的优势包括UCSF CTSI和K30临床研究课程奖的资源，几个K12培训赠款，从中招募学员，一个独特的正式导师培训计划，以及资源的可用性，以促进初级POR研究人员的研究。候选人有她的部门，UCSF CTSI和以患者为导向的研究合作者的热情支持，以追求她的研究目标。K24项目提供的受保护的时间对于候选人继续指导致力于女性下尿路患者导向研究的“下一代”研究人员以及推进肥胖-UI/LUTS关联的创新研究至关重要。

 DESCRIPTION (provided by applicant): Urinary incontinence (UI) and lower urinary tract symptoms (LUTS) affect almost half of US women and cause substantial distress, diminished quality of life, and dramatic limitations in daily functioning. Obesity, a US and worldwide epidemic associated with enormous health and quality of life impact, is one of the strongest independent risk factors for UI and weight loss is an effective treatment for UI. However, the mechanisms by which obesity promotes UI and LUTS and why weight loss is an effective or UI in women are poorly understood. This proposal outlines a 5-year K24 Midcareer Investigator Award in Patient-Oriented Research (POR) renewal application for the candidate to expand her mentoring work with early career patient oriented researchers and promote a multidisciplinary, translational research paradigm focused on the association of weight and weight loss with UI and LUTS. In addition to mentoring plans, the proposal outlines specific aims to continue to advance our understanding of the association of UI, LUTS, and obesity in women by examining the effect of weight and weight loss on UI/LUTS in women, the possible roles of inflammation, physical activity, stress, and body habitus in the relationship between obesity and UI/LUTS, and facilitate the translational development of novel approaches to treatment and prevention of these conditions. The goals of this patient-oriented research and mentoring proposal will be achieved by efficiently leveraging existing resources, including ongoing NIH-funded clinical trials, comprehensive datasets, and productive research collaborations. The candidate's long-term goals are to be a leader in UI research, to contribute substantially to our understanding and approaches to the treatment and prevention of UI and LUTS, and to mentor the "next generation" of investigators interested in the epidemiology and treatment of female incontinence. Elucidating the mechanisms of the association between obesity with UI and LUTS in women will facilitate the translational development of novel approaches to treatment and prevention of these conditions. Strengths of the candidate include her formal training in research methods, history of research productivity and NIH funding, and a successful track record of mentoring junior trainees. Strengths of the institution include the resources of the UCSF CTSI and K30 Clinical Research Curriculum Award, several K12 training grants from which to recruit mentees, a unique formal mentor training program, and the availability of resources to foster research of junior POR investigators. The candidate has the enthusiastic support of her department, the UCSF CTSI, and patient-oriented research collaborators to pursue her research goals. The protected time provided by the K24 program is critical for the candidate to continue mentoring the "next generation" of investigators committed to patient-oriented research in the female lower urinary tract and advancing innovative research on the obesity-UI/LUTS associations.