Nonhuman Primate Core

项目总结（见说明）; 位于杜兰国家灵长类动物研究中心（TNPRC）的非人类灵长类动物（NHP）核心（Core H）的使命是为宾夕法尼亚大学CFAR研究人员提供高度整合的临床和实验室资源以及使用与艾滋病相关的NHP模型的专业知识。“核心”由安德鲁·拉克纳领导，普雷斯顿、马克思、罗纳德·维齐和马塞洛·黑田担任其他关键人员。核心H通过加强和促进CFAR调查人员在NHP中进行艾滋病毒/SIV相关研究的能力，为初级调查人员提供指导和现场培训，以及促进TNRRC和CFAR调查人员之间的科学合作，为CFAR增加了价值。具体目标是：（1）在使用NHP的研究的所有阶段提供监督和协助，支持CFAR研究者项目和建议，并提供资源，协助实验设计，并遵守所有动物福利和生物安全要求;（2）为分配到CFAR项目的NHP提供住房，临床护理，畜牧业和其他常规和必要的服务;（3）为利用NHP的研究提供技术专长和实验室支持;（4）支持NHP试点赠款计划（独立于核心B运行的发展试点计划，但与之互补），旨在鼓励初级和新研究者使用NHP模型;（5）为以前没有与NHP合作过的初级和新研究人员提供教育，培训和指导;（6）激励和促进将基于实验室的研究结果转化为NHP实验。核心H和CFAR之间的合作得到了联合主办的以NHP艾滋病毒/SIV研究为重点的专题讨论会和通过视频会议链接与TNPRC整合的系列研讨会的促进。核心H包括专门的临床、实验室和咨询部分。核心执行各种专业服务，包括原位杂交，免疫组织化学，共聚焦显微镜和图像分析。核心H还通过培训和教育CFAR成员及其学生和博士后使用NHP模型，参与CFAR的辅导使命。核心绩效评估是CFAR年度战略规划过程的一部分。核心H还将在与CFAR新成立的科学工作组合作方面发挥积极作用。在当前周期，核心H支持了12个NHP试点项目，与20名CFAR调查人员密切合作，为6名学生和/或博士后提供现场培训，并为20份出版物和8份NIH赠款做出了贡献。

PROJECT SUMMARY (See instructions); The mission ofthe Nonhuman Primate (NHP) Core (Core H), located at the Tulane National Primate Research Center (TNPRC), is to provide to Penn CFAR investigators highly integrated clinical and laboratory resources and expertise in using NHP models relevant to AIDS. The Core is lead by Andrew Lackner with Preston Marx, Ronald Veazey, and Marcelo Kuroda as additional key personnel. Core H adds value to the CFAR by enhancing and facilitating the ability of CFAR investigators to perform HIV/SIV-related studies in NHPs, providing mentorship and on-site training to junior investigators, and promoting scientific collaborations between the TNPRC and CFAR investigators. Specific goals are to (1) provide oversight and assistance in all phases of research using NHPs, supporting CFAR investigator projects and proposals and providing resources, assistance with experimental design, and compliance with all animal welfare and biosafety requirements; (2) provide housing, clinical care, animal husbandry, and other routine and necessary services for NHPs assigned to CFAR projects; (3) provide technical expertise and laboratory support for studies utilizing NHPs; (4) support a NHP Pilot Grants Program (separate from but complementary to the Developmental Pilot Program run by Core B) designed to encourage junior and new investigators to use NHP models; (5) provide education, training and mentoring to junior and new investigators who have not previously worked with NHP; and (6) stimulate and facilitate translation of bench-based findings to NHP experimentation. Collaborations between Core H and the CFAR are facilitated by jointly sponsored symposia focused on NHP HIV/SIV research and a seminar series integrated with TNPRC via video-conference links. Core H includes specialized clinical, laboratory and consultative components. The Core performs a variety of specialized services including in situ hybridization, immunohistochemistry, confocal microscopy and image analysis. Core H also participates in the CFAR's mentoring mission by training and educating CFAR members and their students and postdocs on use of NHP models. Core performance is evaluated as part ofthe CFAR's annual strategic planning process. Core H will also play an active role in working with the CFAR's newly formed scientific working groups. In the current cycle Core H has supported 12 NHP Pilot Projects, closely worked with 20 CFAR investigators, provided onsite training for 6 students and/or post docs, and contributed to 20 publications, and 8 NIH grants.