Training in Multi-scale Analysis of Biological Structure and Function

描述（由申请人提供）：这是加州大学圣地亚哥分校NIBIB生物结构和功能多尺度分析研究生培训计划的更新。博士预科学员只从多尺度生物学的正式跨学科博士专业中抽取，来自七个高排名参与的家庭博士课程（生物工程，生物科学，生物医学科学，化学与生物化学，机械与航空航天工程，神经科学和物理学）的学生在第一个研究生课程结束时申请加入。这个跨学科项目汇集了来自生物、工程、物理和健康科学的43名教师和目前的39名学生，目标是培养能够跨越学科界限解决从分子到有机体的生物组织尺度的重要生物医学问题的新型科学家骨干。培训课程的核心特点是七门专业技术（包括质谱，光学和电子显微镜，磁共振成像，组织工程和多尺度计算建模）的研究生动手实验课程，用于测量，操纵和分析生物结构和功能，跨越一系列物理尺度。对生物结构和功能的多尺度分析的科学关注反映了现代生物医学科学在开发和应用从物理、工程、生物和健康科学到生物医学综合问题的新颖定量方法方面的基本挑战。定期项目活动，包括双周研究生研讨会，年度专题讨论会和务静会，课程开放日活动和季度项目会议，促进来自不同学科的学生和教师之间的互动。双重指导的培训计划吸引了来自各个学科的优秀研究生，提供了独特的设施和跨学科研究生研究机会，并成功地促进了在重要领域的新的跨学科合作，包括人类遗传学，发育和癌症，神经，心血管和肌肉骨骼系统的疾病和紊乱，诊断和治疗。此更新申请建议继续培养最多样化的学生群体，使其成为生物功能结构集成多尺度分析的有效领导者。它将开发至少一门新的定量细胞生物学实验课程，并积极参与一项研究

DESCRIPTION (provided by applicant): This is a renewal of an NIBIB Graduate Training Program in Multi-Scale Analysis of Biological Structure and Function at the University of California San Diego. Pre-doctoral trainees are drawn exclusively from a formal Interdisciplinary Ph.D. specialization in Multi-Scale Biology, which students from seven highly ranked participating home doctoral programs (Bioengineering, Biological Sciences, Biomedical Sciences, Chemistry and Biochemistry, Mechanical and Aerospace Engineering, Neurosciences and Physics) apply to join at the end of their first of graduate studies. This interdisciplinary program brings together 43 faculty and currently 39 students from the biological, engineering, physical and health sciences with the goal of training a new cadre of scientist who can cross disciplinary boundaries to solve important biomedical problem that span scales of biological organization from molecule to organism. A central feature of the training curriculum is seven hands-on graduate laboratory courses in specialized technologies (including mass spectrometry, light and electron microscopy, magnetic resonance imaging, tissue engineering and multi-scale computational modeling) for measuring, manipulating and analyzing biological structure and functions across a range of physical scales. The scientific focus on multi-scale analysis of biological structure and function reflects a fundamental challenge of modern biomedical science in developing and applying novel quantitative approaches from the physical, engineering, biological and health sciences to integrative problems in biomedicine. Regular program activities including bi-weekly graduate seminars, annual symposia and retreats, course open house events and quarterly program meetings promote interactions between students and faculty from different disciplines. The dual-mentored training program attracts outstanding graduate students from all disciplines, provides access to unique facilities and interdisciplinary graduate research opportunities, and is successful in promoting new interdisciplinary collaborations in important areas including human genetics, development and cancer, diseases and disorders of the nervous, cardiovascular, and musculoskeletal systems, diagnostics and therapeutics. This renewal application proposes to continue to train the most diverse student body to be effective leaders in structurally integrated multi-scale analysis of biological function It will develop at least one new lab course in Quantitative Cell Biology and participate actively in a new campus-wide initiative in Quantitative Biosciences.