UAB Center for AIDS Research

描述(由申请人提供)：UAB CFAR的使命是支持UAB调查人员在社区、美国和世界各地开展多学科的前沿研究，研究艾滋病毒和相关疾病的预防、发病机制、治疗、临床护理和心理社会表现。25年来，该中心在支持其成员的研究活动方面发挥了至关重要的作用，这些活动导致了范式转变的发现，包括：发现艾滋病毒-1准物种多样性，检测艾滋病毒-1 这些研究包括：血浆中的RNA，急性和慢性感染中的病毒动力学，目前批准的7种治疗方法的首个人类第一阶段临床研究，艾滋病毒-1的人畜共患疾病的起源，以及直接使用结果研究数据为临床实践提供信息。战略规划活动将重点放在我们未来5年的科学议程上，以解决：艾滋病毒致病机制、艾滋病毒治疗时代的自然历史、药物发现和预防。CFAR的目标反映了这一现代议程，并进一步推动了我们对创新的、多学科的艾滋病研究的承诺，包括：1.为艾滋病毒/艾滋病研究活动提供一个中央机构重点，强调CFAR成员和更广泛的艾滋病毒/艾滋病研究界之间的有效沟通和合作。2.通过鼓励跨学科研究和向中心调查人员提供关键的共享资源设施以及行政和财政管理支助，提高正在进行的研究方案的生产力。3.使用稳健的战略规划方法，确定与现有CFAR项目相一致的新研究机会和优先事项，并在教师兴趣和大学能力明显的情况下，培育新的研究项目。4.刺激青少年和青少年的进入 通过年轻研究人员的指导计划和同行审查的发展赠款计划，将现有教员纳入艾滋病毒/艾滋病研究计划。5.在反映阿拉巴马州、美国和世界各地艾滋病毒/艾滋病研究进展的领域，促进教师招聘和项目发展。UAB CFAR在刺激艾滋病毒/艾滋病研究方面的成功体现在：外部资金从1988年的600万美元增加到目前的8600多万美元，自2009年以来招聘了24名以上的艾滋病毒/艾滋病调查员，出版了引人注目的出版物，并获得了杰出的机构支助。。

DESCRIPTION (provided by applicant): The mission of the UAB CFAR is to support UAB investigators in the conduct of multidisciplinary, cutting edge research in the prevention, pathogenesis, therapeutics, clinical care, and psychosocial manifestations of HIV and related disorders in the community, within the US and around the world. For 25 years, the Center has played a vital role in supporting research activities of its members that have led to paradigm-shifting discoveries, including: the discovery of HIV-1 quasi-species diversity, detection of HIV-1 RNA in plasma, viral dynamics in acute and chronic infection, first-in-human phase 1 clinical studies of 7 currently approved therapies, the zoonotic origins of HIV-1, and the direct use of outcomes research data to inform clinical practice. Strategic planning activities have focused our scientific agenda over the next 5 years to address: HIV pathogeneses, the natural history of HIV in the treatment era, drug discovery, and prevention. The objectives of the CFAR reflect this modern agenda and further our commitment to innovative, multidisciplinary AIDS research, including: 1. Provision of a central institutional focus for HIV/AIDS research activities that emphasize effective communication and collaboration among CFAR members and the wider HIV/AIDS research community. 2. Enhancement of productivity of ongoing research programs by encouraging interdisciplinary research and by providing critical shared resource facilities and administrative and fiscal management support to Center investigators. 3. Use of robust strategic planning methods to identify new research opportunities and priorities that align with existing CFAR programs and foster new research programs where none are in existence but where faculty interest and University capacity is evident. 4. To stimulate the entry of junior and established faculty into HIV/AIDS research programs through mentoring programs for young investigators and by a peer-reviewed Developmental Grants Program. 5. To stimulate faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research in Alabama, the United States, and around the world. The success of the UAB CFAR in stimulating HIV/AIDS research is reflected in the growth in extramural funding from $6.0 million in 1988 to over $86 million currently, in the recruitment of more than 24 HIV/AIDS investigators since 2009, high profile publications, and in the garnering of outstanding Institutional support. .