Mentoring in Patient Oriented Research on Asthma and the Indoor Environment

应聘者描述(由申请人提供)：应聘者目前是约翰霍普金斯大学儿科副教授，儿科过敏学家/免疫学家、流行病学家和环境健康科学家，其广泛的职业目标是了解环境对哮喘的影响，从而产生可行和可行的公共卫生干预措施，以预防哮喘和降低哮喘发病率。由于必须了解微生物、过敏原和污染物之间的复杂相互作用，以便在预防和治疗过敏性疾病的环境控制策略方面取得重大进展，该项目的一个主要目标是扩大她的研究计划，以研究环境微生物暴露对哮喘的影响。此外，候选人在指导以患者为导向的研究(POR)受训人员方面有着良好的记录，并建议通过教学和指导学习相结合的方式发展高级指导技能。因此，这项建议的第二个目的是保护她的指导和进一步发展指导技能的时间。指导技能和研究发展将部分在拟议的研究项目的背景下进行，该项目旨在测试环境暴露于SE+金黄色葡萄球菌会以SE特异性IgE依赖的方式导致城市儿童哮喘发病率的假设。

DESCRIPTION (provided by applicant): The candidate is currently an Associate Professor of Pediatrics at Johns Hopkins and a pediatric allergist/immunologist, epidemiologist, and environmental health scientist whose broad career goal is to develop an understanding of the effects of the environment on asthma that results in feasible and actionable public health interventions to prevent asthma and reduce asthma morbidity. As the complex interplay between microbes, allergens, and pollutants must be understood in order to make significant progress in environmental control strategies for prevention and treatment of allergic disease, one major aim of this project is to extend her research program to study the effects of environmental microbial exposures on asthma. In addition, the candidate has a strong track record of mentoring trainees in patient-oriented research (POR) and proposes to develop advanced mentorship skills with a combination of didactic and mentored learning. Thus, the second aim of this proposal is to protect her time for mentorship and further development of mentoring skills. The mentorship skills and research development will occur, in part, in the context of the proposed research project, which aims to test the hypothesis that environmental exposure to SE+ S. aureus causes asthma morbidity in urban children in a SE-specific IgE dependent manner.