Path to Improved Risk Stratification

 描述(申请人提供)：心脏性猝死是一个主要的公共卫生问题，每年约有18万至40万人死亡。由于院外复苏的有效性和成功率较低，因此在事件发生前尝试并识别有心脏猝死风险的人已被列为高度优先事项。如果可以做到这一点，就可以采取一些治疗措施来减轻这种风险。然而，尽管进行了几十年的研究，并投入了大量的时间、精力和研究资金，但目前还没有一种理想的或前夕可以接受的方法来进行心脏性猝死的风险分层。为了在这一领域取得更快进展，可以采取的一种办法是促进不同利益攸关方--调查人员、政府机构和工业界--之间的更好协调。虽然所有这些都归因于风险分层的需要，但每一组都有不同的优先事项，因此从不同的角度处理问题。NFP是由Jeffrey Goldberger博士创立的非营利性智囊团，其使命是作为联络点，帮助组织合理、协调的计划，制定、评估和实施预防心脏性猝死的风险分层策略。为了改善风险分层的途径，NFP于2005-2012年在芝加哥以及2014年和2015年在华盛顿组织了年度单日会议，与会者包括：1)风险分层、预防心脏性猝死的临床试验、流行病学和卫生经济学领域的医生领导；2)相关政府机构的代表；3)业界代表。会议议程旨在找出我们知识中的重要差距，并为如何最好地填补这些差距制定战略。这些会议在风险分层方面产生了新的努力，并帮助指导了一些正在开发中的临床试验。每次会议的议程是评估前一次会议的进展情况，审查与风险分层相关的新信息，讨论与正在进行的临床试验相关的问题，获得新试验规划的最新情况，审查与风险分层相关的科学/统计学/经济学问题，并探索我们的知识库中存在空白的新领域。在确定了差距之后，现在更加重视制定一项行动计划，以弥补已查明的一些差距。鉴于推进风险分层领域需要了解的大量信息，这一努力为有关各方提供了一个重要的宣传平台，并鼓励合作和开发创新方法。 叙述：心脏性猝死风险分层改进之路会议是一个由多个利益相关者组成的智囊团，他们对提高我们在遭受这一事件之前识别RIS患者心脏性猝死的能力感兴趣。由于这是一个重大的公共卫生问题，每年导致约180000至400000人死亡，需要共同努力克服在这一领域取得进展的障碍。

 DESCRIPTION (provided by applicant): Sudden cardiac death is a major public health problem with approximately 180,000 to 400,000 deaths annually. Because of the low efficacy and success rates of out-of-hospital resuscitation, a high priority has been set to try and identif individuals at risk for sudden cardiac death prior to the event. If this can be done, there are treatments that can be instituted to mitigate this risk. However, despite decades of research, and significant investments of time, effort, and research dollars, there is not yet an ideal or eve acceptable approach to risk stratification for sudden cardiac death. One approach that could be initiated to engender more rapid progress in this area is to promote better coordination among the various stakeholders - investigators, government agencies, and industry. Although all are vested in the need for risk stratification, each group has different sets of priorities and therefoe approaches the problem from different perspectives. The Path to Improved Risk Stratification, NFP is a not-for-profit think tank founded by Dr. Jeffrey Goldberger whose mission is to serve as a focal point to help organize a rational, coordinated plan for developing, evaluating, and implementing risk stratification strategies for prevention of sudden cardiac death. The Path to Improved Risk Stratification, NFP has organized annual single day meetings in Chicago from 2005-2012 and in Washington in 2014 and 2015 with: 1) physician leaders in the area of risk stratification, clinical trials in prevention of sudden cardiac death, epidemiology, and health economics; 2) representatives from the relevant government agencies; 3) representatives from industry. The meeting agendas are designed to identify important gaps in our knowledge and to strategize how those gaps can best be filled. These meetings have resulted in new efforts in risk stratification and have helped guide some clinical trials that have been in development. The agenda for each meeting is to evaluate progress from the prior meeting, review new information relevant to risk stratification, discuss issues related to ongoing clinical trials, obtain updates n planning of new trials, review scientific/statistical/economics issues related to risk stratificatin, and explore new areas that are gaps in our knowledge base. Having identified the gaps, there is now greater emphasis on developing an action plan to address some of the identified gaps. Given the vastness of the information that needs to be understood to advance the field of risk stratification, this effort provides an important sounding board for those involved and encourages collaboration and the development of innovative approaches. Narrative: The Path to Improved Risk Stratification for Sudden Cardiac Death conference is a think tank of multiple stakeholders interested in improving our ability to identify patients at ris for sudden cardiac death prior to suffering this event. As this is a major public health problem, leading to approximately 180000 to 400000 deaths annually, a collaborative effort is necessary to overcome the barriers to advancement in this field.