Controlled Environment Facility Core

环境暴露和疾病中心(CEED)的使命是通过以下方式改善人类健康 进行跨学科研究以阐明总环境、基因组和表观基因组是如何 相互作用，以降低疾病风险。CEED研究的重点是：1)评估和模拟暴露；2) 发现和应用将暴露与致病机制联系起来的生物反应指标， 3)制定和实施有针对性的预防、干预和治疗战略，4)减少 通过影响公共政策、规划和监管进行曝光，以及5)吸引和告知利益攸关方。 通过与精密医学的类比，CEED设想整合来自暴露生物学的数据， 基因组学，表观遗传学和微生物学，以评估暴露，生物反应，机制 发病机制和疾病预防将对环境健康的未来产生重大影响。CEED 愿景是通过整合临床、医疗和医疗等领域的 基础的和基于人群的研究，利用获得的信息来预防和/或治疗环境 疾病。该战略是将该中心在以下领域的长期专业知识的广度和深度结合起来 在暴露生物学、表观基因组学和微生物学领域拥有新能力的环境健康研究。这个 具体目标是：目标1：推动基础、临床和人口研究朝着精确的环境健康方向发展 通过：一)促进协作、跨学科的研究环境，二)支持创新研究和 通过试点赠款资助新兴科学，以及三)提供具有成本效益的设施核心访问， 保持最先进的技术和专业知识。目标2：提供培训和指导机会 创新和新兴环境健康研究方面的初级研究人员和资深研究人员 通过：一)指导委员会和结构化的指导课程，二)合作研究，三)职业 发展奖和试点项目赠款，以及四)与其他NIEHS扩大培训的机会 中锋。目标3：通过以下方式加强和扩大与社区伙伴的现有关系：i)促进 CEED研究人员和社区合作伙伴之间的双向互动，以确定环境 关注的问题和预期的结果，ii)开发满足社区卫生需求的研究方案，以及 三)向社区和卫生专业人员提供研究成果、教育材料和专门知识； 使他们能够最大限度地减少接触，并影响公共卫生政策。目标4：将研究成果转化为 地方、州和联邦政府机构的利益相关者提供风险缓解方面的指导，以 影响公共政策，并支持减少暴露和改善环境健康的立法。

The mission of the Center for Environmental Exposure and Disease (CEED) is to improve human health by performing transdisciplinary research to elucidate how the total environment, the genome and the epigenome interact to mitigate the risk of disease. CEED research focuses on: 1) assessing and modeling exposures, 2) discovering and applying biological response indicators which link exposures to mechanisms of pathogenesis, 3) developing and implementing targeted prevention, intervention, and treatment strategies, 4) reducing exposures by influencing public policy, planning and regulation, and 5) engaging and informing stakeholders. By analogy with Precision Medicine, CEED envisions that the integration of data from exposure biology, genomics, epigenetics and microbiomics to assess exposures, biological responses, mechanisms of pathogenesis and disease prevention will significantly impact the future of environmental health. The CEED vision is to lead the development of precision environmental health research through the integration of clinical, basic, and population-based studies, using the acquired information to prevent and/or treat environmental disease. The strategy is to combine the Center's long-standing breadth and depth of expertise in environmental health research with new capabilities in exposure biology, epigenomics, and microbiomics. The Specific Aims are: Aim 1: Move basic, clinical and population research toward precision environmental health by: i) fostering a collaborative, transdisciplinary research environment, ii) supporting innovative research and emerging science through Pilot grant funding, and iii) providing cost-effective access to Facility Cores that maintain state-of-the-art technologies and expertise. Aim 2: Provide training and mentoring opportunities to junior investigators and established researchers in innovative and emerging environmental health research through: i) mentoring committees and a structured mentoring curriculum, ii) collaborative research, iii) Career Development Awards and Pilot Project grants, and iv) opportunities for expanded training with other NIEHS Centers. Aim 3: Strengthen and expand existing relationships with community partners by: i) facilitating bidirectional interactions among CEED researchers and community partners to identify environmental concerns and desired outcomes, ii) developing research programs that address community health needs, and iii) providing research results, educational materials and expertise to communities and health professionals, enabling them to minimize exposures and influence public health policy. Aim 4: Translate research findings to stakeholders in local, state and federal government agencies to provide guidance on mitigation of risk, to influence public policy, and to support legislation that reduces exposure and improve environmental health.