Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease

项目总结 我们消化健康中心(DHC)的总体目标：儿科消化床旁研究 疾病是为了促进对基本过程和致病机理的深入研究 儿童消化系统疾病的机制，并产生恢复消化健康的创新治疗方法。这个 DHC的第二个获奖期非常成功，核心服务发展到满足科学 创新调查人员的需求，83名调查人员的强大研究基础和3050万美元的校外资金 过渡到R01资助的消化系统疾病相关基金、试点和可行性(P/F)获奖者 调查人员，以及动态富集型系列。这一成功的轨迹将在未来几年由 促进研究和促进部门间和部门间的合作，以保持坚实的关键 大量参与消化系统疾病研究，重点是翻译研究。具体来说，我们的长期目标是 通过更好的诊断、治疗和结果改善儿童健康 我们在四个关键重点领域的高度创新工作：1)肝脏疾病建模，2)消化系统疾病和 免疫，3)消化系统疾病和肥胖症，4)翻译胚胎学。每个焦点领域都带来了 对儿童消化健康有潜在影响的机会，有助于推动国家研究 议程，并创造一个独特的环境，将研究整合到患者护理中。重点领域是相互关联的 由三个互补和独特创新的生物医学研究核心(基因分析核心， 综合形态核心、多能干细胞和类器官核心)和临床 管理核心的组成部分，以促进以患者为基础的研究。他们共同组成了一个强大的 基础设施，促进个性化和预测性医疗方法的发展 胃肠道疾病的遗传学和分子基础，以及考虑到胃肠道疾病基本机制的治疗方法 疾病。我们的工作模式促进实验室发现，创造翻译研究机会 这将导致在患者样本中进行验证，随后是临床试验。加强儿科消化 在疾病方面，DHC将促进其研究人员和来自其他学科的研究人员之间的合作。会的 还将资助前景看好的初级调查人员的P/F项目，并将赞助一个动态浓缩计划 科学研讨会、讲习班和专题讨论会。有了这些策略和特别的支持 作为一家机构，DHC处于有利地位，可以催化儿科消化系统疾病的转化研究。

PROJECT SUMMARY The overall goal of our Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease is to promote research that will yield insights into the fundamental processes and pathogenic mechanisms of digestive disease in children and generate innovative treatment to restore digestive health. The second award period of the DHC was very successful, with Core services that evolved to meet the scientific needs of innovative investigators, a strong Research Base of 83 investigators and $30.5 million of extramural digestive disease-related funds, Pilot and Feasibility (P/F) Awardees that transitioned to R01-funded investigators, and a dynamic enrichment series. This trajectory of success will be pursued in future years by fostering research and promoting interdivisional and interdepartmental collaboration to maintain a solid critical mass in digestive disease research, with a focus on translational research. Specifically, our long term goals are to improve child health through better diagnosis, treatments and outcomes that will emerge from highly innovative work in our four key focus areas: 1) Liver disease modeling, 2) Digestive disease and immunity, 3) Digestive disease and obesity, and 4) Translational embryology. Each focus area brings opportunities for potential impact on the digestive health of children, helps advance the national research agenda, and creates a unique environment to integrate research into patient care. The focus areas are linked by three complementary and uniquely innovative Biomedical Research Cores (Gene Analysis Core, Integrative Morphology Core, and Pluripotent Stem Cell and Organoid Core) and by a Clinical Component of the Administrative Core to facilitate patient-based research. Collectively they form a powerful infrastructure that fosters the development of personalized and predictive medical approaches based on the genetics and molecular basis of GI disorders, and of therapies that take into account basic mechanisms of disease. Our working model promotes laboratory discoveries to generate translational research opportunities that lead to validation in patient samples and is followed by clinical trials. To strengthen pediatric digestive disease, the DHC will foster collaboration among its investigators and investigators from other disciplines. It will also fund highly promising P/F Projects for junior investigators and will sponsor a dynamic enrichment program of scientific seminars, workshops and symposia. With these strategies and an exceptionally supportive institution, the DHC is well positioned to catalyze translational research in pediatric digestive disease.