EDAC: ENCODE Data Analysis Center

项目摘要 DNA元件百科全书（Encyclopedia of DNA Elements，ENCODE）项目的目标是将DNA中所有的功能元件分类， 通过高通量数据的整合和分析来研究人类基因组。我们建议继续 ENCODE数据分析中心（EDAC，DAC）将在分析和 整合来自ENCODE项目的数据，并与其他ENCODE小组密切合作，包括 数据协调中心。我们建议的DAC团队（Zhiping Weng，Mark Gerstein，Manolis Kellis，Roderic 放大图片作者：X. Shirley Liu，Anshul Kundaje和William Noble）在广泛的领域拥有专业知识， 包括转录调控，表观遗传学，进化，基因组学和蛋白质组学，调控RNA， 生物物理学和计算生物学，他们是机器学习，统计遗传学， 网络和基因注释。这些调查人员也有成功合作的历史 在大型财团中，特别是与其他ENCODE集团。他们的出版记录表明， 以协同方式产生影响力大的科学和有益的资源， 生物医学社区。 拟议的发展援助委员会将追求以下四个目标：分析和集成来自 广泛的功能基因组学项目;目标2.作为信息资源，支持 ENCODE分析工作组的活动;目标3。创建高质量的DNA元素百科全书 在人类和小鼠基因组中;目的4.评估ENCODE数据的质量和效用，并提供 向NHGRI和财团提供反馈。

PROJECT SUMMARY The goal of the Encyclopedia of DNA Elements (ENCODE) project is to catalog all functional elements in the human genome through the integration and analysis of high-throughput data. We propose to continue the ENCODE Data Analysis Center (EDAC, DAC) which will provide support and leadership in analyzing and integrating data from the ENCODE project as well as work closely with other ENCODE groups including the Data Coordination Center. Our proposed DAC team (Zhiping Weng, Mark Gerstein, Manolis Kellis, Roderic Guigo, Rafael Irizarry, X. Shirley Liu, Anshul Kundaje, and William Noble) has expertise across a wide range of fields including transcriptional regulation, epigenetics, evolution, genomics and proteomics, regulatory RNA, biophysics, and computational biology, where they are the leaders in machine learning, statistical genetics, networks, and gene annotation. These investigators also have a history of successfully working collaboratively in large consortia, particularly with other ENCODE groups. Their publication records demonstrate their synergistic approach to producing high-impact science and useful resources that benefit the broader biomedical communities. The proposed DAC will pursue the following four aims: Aim 1. Analyze and integrate data and metadata from a broad range of functional genomics projects; Aim 2. Serve as an informatics resource by supporting the activities of the ENCODE Analysis Working Group; Aim 3. Create high-quality Encyclopedias of DNA elements in the human and mouse genomes; Aim 4. Assess quality and utility of the ENCODE data and provide feedback to NHGRI and the Consortium.