Michigan Nutrition Obesity Research Center

 描述(由申请人提供)：密歇根营养肥胖研究中心(MNORC)最初于2010年获得资助，旨在支持、整合和加强密歇根大学教职员工中与肥胖和营养相关的研究。MNORC的目的是创造一种环境，鼓励和使来自临床前、临床和转化研究学科的研究人员整合先进的表型和计算工具，以更全面地定义因饮食营养成分或数量而产生的个人和群体特征。这将通过提供核心实验室基础设施、教育和培训机会以及大大小小的试点赠款来实现，以提高研究生产率。MNORC扩大了研究基础设施和核心产品，以满足研究界的需求，并支持在密歇根大学校园内扩展营养和肥胖研究。这一点突出表现在260万美元的投资，以扩大儿童肥胖研究，创建表观基因组学核心，并创建体外和体内光遗传学能力，以满足研究人员的需求。MNORC有106名研究基地教员，每年的直接赠款总额为39,708,277美元。MNORC的核心包括行政核心，它将监督和整合中心的研究、临床和教育职能，包括每年一次的研讨会、研讨会系列、对本科生、营养师、医学生、家庭工作人员和研究人员的广泛营养和肥胖护理和研究方面的培训；人类表型核心，将为住院和门诊环境中对人类进行复杂的代谢和神经行为测试提供专门知识和基础设施；分子表型核心，将继续支持有针对性和无针对性的代谢组学研究(通过区域综合代谢组学资源核心(U24)910万美元的资助)以及表观组学和微生物组科学方面的新举措；动物表型核心将为代谢和分子表型分析提供服务，并通过支持光遗传学技术提高啮齿动物模型的神经行为表型分析能力；综合生物统计和信息学核心将提供人员，协助研究人员设计实验，将分子和临床表型分析、数据库开发和先进的生物信息学工具整合、解释、可视化和报告分子、代谢和神经行为数据。MNORC将继续支持体重管理计划，该计划将研究整合到非常成功的成人临床减肥计划中。许多研究人员访问了通过该程序收集的患者、生物样本和数据，用于他们自己的研究。在下一个赠款周期，我们将支持一个新资助的试点项目-密歇根州儿科综合体重管理中心的研究。在下一个资助期内，MNORC将继续与研究基地沟通，以确定新的支持领域，并根据社区的需要调整提供的服务。

 DESCRIPTION (provided by applicant): The Michigan Nutrition Obesity Research Center (MNORC) was initially funded in 2010 to support, integrate and enhance research related to obesity and nutrition among the faculty of the University of Michigan. The of the MNORC is to create an environment to encourage and enable researchers from preclinical, clinical and translational research disciplines to integrate advanced, phenotyping and computational tools to more fully define individual and population characteristics that arise in response to dietary nutrient composition or amount. This will be accomplished by providing core laboratory infrastructure, educational and training opportunities and large and small pilot grants to enhance research productivity. The MNORC has expanded the research infrastructure and Core offerings in response to the needs of the research community and has supported the expansion of nutrition and obesity research across the U-M campus. This is highlighted by the $2.6 million investment to expand pediatric obesity research and the creation of an epigenomics core and creation of in vitro and in vivo optogenetics capabilities in response to investigator needs. MNORC has 106 Research Base faculty with a total of annual direct grant support of $39,708, 277. The MNORC Cores include the Administrative Core, which will oversee and integrate the research, clinical and education functions of the Center, including an annual symposium, seminar series, training for undergraduates, dieticians, medical students, housestaff and fellows in the breadth of nutrition and obesity care and research; the Human Phenotyping Core, which will provide expertise and infrastructure for sophisticated metabolic and neurobehavioral testing of humans in inpatient and outpatient settings; the Molecular Phenotyping Core, which will continue supporting targeted and untargeted metabolomics profiling (enhanced by the $9.1 million funding of the Regional Comprehensive Metabolomics Resource Core (U24)) as well as new initiatives in epigenomics and microbiome sciences; the Animal Phenotyping Core which will provide services for the metabolic and molecular phenotyping and increase the capability for neurobehavioral phenotyping of rodent models by supporting optogenetics technology; and the Integrative Biostatistics and Informatics Core, which will provide personnel to assist investigators in design of experiments that integrate molecular and clinical phenotyping, database development, and advanced bioinformatics tools for integration, interpretation, visualization and reporting of molecular, metabolic and neurobehavioral data. The MNORC will continue to support the Weight Management Program which integrates research into a highly successful adult clinical weight loss program. Numerous investigators access the patients, biosamples and data collect through the program for their own research. In the next grant cycle, we will support research in a newly funded pilot project the Michigan Pediatric Comprehensive Weight Management Center. Through the next funding period, the MNORC will continue to communicate with the research base to identify new areas for support and adjust the service offerings consistent with the needs of the community.