Aberrant ependymal development and the formation of hydrocephalus

胎儿脑积水是一种常见的神经发育疾病，与严重的智力障碍有关。室管膜细胞层作为脑组织和脑室空间之间的屏障，其破坏是脑积水的主要原因。尽管这些细胞很重要，但我们对调节其产生的分子机制知之甚少。这个项目将确定控制室管膜层建立的关键信号通路。

Foetal hydrocephalus is a prevalent neurodevelopmental condition associated with severe intellectual impairment. Breakdown of the ependymal cell layer, which acts as a barrier between brain tissue and the ventricular space, is a major cause of hydrocephalus. Despite the importance of these cells, we have little understanding of the molecular mechanisms that regulate their production. This project will identify critical signalling pathways governing the establishment of the ependymal layer.