UAB Diabetes Research Center

描述（由申请人提供）：本提案将继续2008年在UAB首次成立的DRTC的进展，并过渡到DRC。该中心的近期目标是促进糖尿病研究的卓越。在过去的4年里，DRC已经激励了UAB研究社区围绕糖尿病的研究，导致成员从115增加到159，并在校外研究经费增加了32.5%。通过这些努力，该中心最终致力于降低糖尿病发病率/死亡率，并为糖尿病研究的培训和职业发展提供良好的环境。我们的具体目标是：1.通过赞助我们的研究者基地明确要求的研究核心设施，促进和加强糖尿病研究。这五个研究核心涵盖了广泛的翻译范围：生物分析REDOX生物学，胰岛细胞生物学，动物生理学，人类生物学和干预与翻译核心。2.通过试点和可行性资助计划加强糖尿病研究，该计划将强调极具前途的初级研究人员的创新，翻译和职业发展。3.赞助一个综合的丰富计划，促进一个优秀的多学科研究者基地，这将加强学习，协作，合议和创新的凝聚力的环境。4.通过响应我们调查人员不断变化的需求，并通过推动新的想法和调查路线的领导，在我们前4年取得的进展的基础上再接再厉。5.强调研究，培训和推广，以满足我们的学员的需求，为我们的患者实现更好的结果，并减轻糖尿病在我们的社区和国家的高负担。6.利用UAB领导层的决心，大量的机构承诺，以及我们社区的慷慨慈善事业，进一步推动在南方腹地发展卓越的糖尿病研究中心。我们的DRC位于美国糖尿病发病率最高的社区，并将研究人员围绕共同主题联合起来，在心脏代谢疾病的背景下研究糖尿病。

DESCRIPTION (provided by applicant): This proposal will continue the progress of the DRTC, first established at UAB in 2008, and the transition to a DRC. The immediate goal of the center is to promote excellence in diabetes research. Over the past 4 years, the DRC has galvanized the UAB research community around the study of diabetes resulting in an increase in membership from 115 to 159, and a 32.5% increase in extramural research funding. Through these efforts, the center ultimately endeavors to decrease diabetes morbidity/mortality, and to provide an outstanding environment for training and career development in diabetes research. Our specific aims are to: 1. Facilitate and enhance diabetes research by sponsoring research core facilities expressly required by our investigator base. The five research cores cover a broad translational spectrum: Bioanalytical REDOX Biology, Islet Cell Biology, Animal Physiology, Human Biology, and Interventions & Translation Cores. 2. Augment diabetes research via a pilot & feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Sponsor an integrated Enrichment Program that promotes a cohesive environment for an outstanding multi-disciplinary investigator base, which will enhance learning, collaboration, collegiality, and innovation. 4. Build upon the progress achieved over our first 4 years by responding to the evolving needs of our investigators and through leadership that impels new ideas and lines of investigation. 5. Emphasize research, training, and outreach that are responsive to the needs of our trainees, achieve better outcomes for our patients, and lessen the high burden of diabetes in our community and nation. 6. Leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to further impel the development of a pre-eminent center of diabetes research excellence in the heart of the Deep South. Our DRC is located in a community with the highest rates of diabetes in the US, and unites investigators around common themes to study diabetes in the context of cardiometabolic disease.