Mouse Genetics Core

摘要 老鼠模型提供了高度易处理的模型，可以用来评估、识别和机械地表征 基因变异在传染病反应中的作用。小鼠遗传学的核心一直处于 设计实验杂交、序列数据集和其他鼠标资源的前沿 调查和扰乱多态免疫网络。在识别多态宿主之后 基因组区域、异常的小鼠品系和不协调的免疫传播或候选基因和途径 来自人类研究(与项目以及系统遗传学和生物信息学密切合作 CORE)，我们将为项目生成各种小鼠实验模型，以进一步评估、识别和 描述这些过程的特征。这些模型将包括对比不同疾病等位基因的F1面板，F2 绘制种群图，以及带有修改的候选基因的小鼠品系。同时，设计 研究病毒疾病的适当实验需要了解其潜在的免疫机制。 个人的构成。因此，核心将确定并进一步表征影响 基础免疫反应；既有细胞内的，也有整个机体水平的。这些数据将是 提供给这些项目，以加强它们对抗病毒和/或不安反应的评估。

Abstract Mouse models provide highly tractable models with which to assess, identify and mechanistically characterize the role of genetic variants on infectious disease responses. The Mouse Genetics Core has been at the forefront of designing experimental crosses, sequence datasets and other mouse resources with which to investigate and perturb polymorphic immune networks. Following the identification of polymorphic host genome regions, aberrant mouse lines, and discordant immune spreads or candidate genes and pathways from human studies (in close collaboration with the Projects and the Systems Genetics and Bioinformatics core), we will generate a variety of mouse experimental models for the Projects to further assess, identify and characterize these processes. These models will include F1 panels contrasting variant disease alleles, F2 mapping populations, and mouse strains with modified candidate genes. Concurrently, designing the appropriate experiments for the study of viral disease requires an understanding of the underlying immune composition of individuals. Therefore, the Core will identify and further characterize genetic variants impacting basal immune responses; both intra-cellular as well as at the whole-organism level. These data will be provided to the projects to enhance their assessment of antiviral and/or perturbed response.