Global Health Research and Training in HIV and Tuberculosis

描述（由申请人提供）：我的长期职业目标是为美国和国际医学科学家开发一个全球健康研究培训计划，重点是艾滋病毒和结核病。该K24提案的目标是通过主要在海地和坦桑尼亚进行研究来培训医生科学家和优秀的博士前学生，并在海地进行一项关于艾滋病毒引起的慢性炎症的新研究项目。美国学员将在海地和坦桑尼亚的国际研究中心度过约60%的时间，这些研究中心拥有现场威尔康奈尔大学的教师，先进的电信和出色的研究培训环境。医生科学家可以在威尔康奈尔医学院攻读临床流行病学和卫生服务研究理学硕士（MS）。研究战略包括在海地的一个新的研究项目，该项目将得到K24艾滋病毒诱导慢性炎症奖（AIM 1）的支持，目前在海地资助的项目（AIMS 2 - 5），以及目前在坦桑尼亚姆万扎的一个新研究基地资助的项目（AIM 6）。共同的主题是，所有项目都以面向病人的艾滋病和结核病研究为重点，并将作为研究学员的培训工具。这些项目包括以下内容：1.慢性炎症作为延迟ART的结果：生物标志物和后遗症2。HIV感染妇女的宫颈癌：前列腺素E2 3的作用。用于诊断和监测治疗的结核病生物标志物4. HIV疫苗和ART临床试验5.耐多药结核病监测与控制6.女性泌尿生殖道血吸虫病和艾滋病毒的相互作用五个项目涉及长期研究的队列在海地，第六个队列在坦桑尼亚。所有研究都有临床和实验室方面，为学员提供广泛的经验。受训者通过开展独立项目和与从事其他研究的同事互动的机会学习。

DESCRIPTION (provided by applicant): My long-term career goal is to develop a global health research-training program for United States and international physician-scientists with a focus on HIV and tuberculosis. The goals of this K24 proposal are to train physician scientists and outstanding pre-doctoral students through the conduct of research primarily in Haiti, and also in Tanzania and to conduct a new research project on HIV induced chronic inflammation in Haiti. United States trainees will spend ~60% of their time at international research sites in Haiti and Tanzania, which have on-site Weill Cornell faculty, advanced telecommunications, and outstanding environments for research training. Physician-scientists may pursue a Master of Science (MS) in Clinical Epidemiology and Health Services Research at Weill Cornell Medical College. The research strategy includes a new research project in Haiti to be supported by the K24 award on HIV induced chronic inflammation (AIM 1), currently funded projects in Haiti (AIMS 2 - 5), and a currently funded project at a new research site in Mwanza, Tanzania (AIM 6). The common theme is that all the projects have patient-oriented research on AIDS and TB as the focus and will serve as training vehicles for research trainees. The projects include the following: 1. Chronic inflammation as a consequence of delayed ART: biomarkers and sequelae 2. Cervical cancer in HIV infected women: role of prostaglandin E2 3. Tuberculosis biomarkers for diagnosis and for monitoring therapy 4. HIV vaccine and ART clinical trials 5. Multidrug resistant tuberculosis surveillance and control 6. Female urogenital schistosomiasis and HIV interactions Five of the projects involve long-term study of cohorts in Haiti, and the sixth a cohot in Tanzania. There are both clinical and laboratory aspects to all studies which offer trainees broad experience. Trainees learn through the conduct of an independent project and the opportunity to interact with colleagues working on studies other than their own.