Center for Engineering Complex Tissues

项目摘要 复杂的工程化组织的制造仍然是再生医学中的一个巨大挑战。这些 复杂的组织--骨、软骨、血管和心脏--以密集的细胞为特征，有花纹 细胞组成和受控的矩阵呈现。建议的生物医学技术资源 中心(BTRC)将通过将三维打印(3DP)策略应用于 复杂组织工程学。这个BTRC汇集了马里兰大学的研究领袖， 莱斯大学和维克森林大学，都是该领域备受尊敬的合作者，领导 复杂组织工程中心的发展(CECT，[Sees-t])。强大而有效 管理领导力将最大限度地提高工作效率，增强持续协作，并确保稳健的财政 以及该BTRC的合规管理。CECT的技术组成部分由3项技术组成 研发项目(R&D)、6个协作项目(CP)和6个服务项目(SP)。 将设立一个外部咨询委员会，为中心的战略方向提供指导和建议 由具有与CECT相关的生物医学专业知识的世界知名研究人员组成。一个本地人 执行委员会(LEC)将协调参与日常工作的各参与机构的努力- 该中心的日常运作。我们还将专注于发展一个致力于开发和利用的社区 通过提供一系列计划来帮助开发和建立这些技术，从而使复杂的工程组织变得更加复杂。 还将制定传播方案，以传播中心的活动，以使 更广泛地使用这些技术。CECT的长期计划是，它将成为 将当前的3DP和组织工程技术转变为新的和改进的日常平台 在再生医学和生物医疗设备开发中的应用。

Project Summary The fabrication of complex engineered tissues remains a grand challenge in regenerative medicine. These complex tissues – bone, cartilage, vasculature, and cardiac – are characterized by dense cellularity, patterned cellular composition, and controlled matrix presentation. The proposed Biomedical Technology Resource Center (BTRC) will address this critical need by applying three-dimensional printing (3DP) strategies to the engineering of complex tissues. This BTRC brings together research leaders at the University of Maryland, Rice University, and Wake Forest University, all highly regarded collaborators in the field, to lead the development of the Center for Engineering Complex Tissues (CECT, [sees-t]). Strong and effective administrative leadership will maximize productivity, enhance ongoing collaborations, and ensure sound fiscal and compliance management for this BTRC. The technical components of CECT consist of 3 Technology Research and Development Projects (TR&Ds), 6 Collaborative Projects (CPs), and 6 Service Projects (SPs). An External Advisory Committee (EAC), that will guide and advise the strategic direction of the Center, will be assembled from world-renowned researchers with biomedical expertise relevant to the CECT. A Local Executive Committee (LEC) will coordinate the effort across the participating institutions involved in the day-to- day operations of the Center. We will also focus on growing a community engaged in developing and utilizing complex engineered tissues by offering a series of programs to help develop and establish these technologies. Communications programs will also be developed for the dissemination of the Center’s activities to enable a broader use of the technologies. The long-term plan for the CECT is that it will become a national hub for transforming current 3DP and tissue engineering technologies into new and improved platforms for everyday uses in regenerative medicine and biomedical device development.