ASPREE- NEURO; aspirin and cerebral microhaemorrhages

脑微出血(CMH)是老年人脑部磁共振成像中常见的血管破裂的微小区域。它们的临床意义尚不清楚--之前的研究已经将它们与血液稀释药的使用、认知能力下降和中风风险联系在一起。这项随机对照试验将确定小剂量阿司匹林是否会在1年和3年后增加健康老年人脑MRI上CMH的数量，以及CMH的数量和位置是否会影响认知功能。

Cerebral Microhaemorrhages (CMH) are tiny areas of blood vessel breakdown commonly found on brain MRIs in the elderly. Their clinical significance is not clear- prior studies have linked them to use of blood thinning medications, cognitive decline and risk of stroke. This randomised controlled trial will determine whether low dose aspirin increases the number of CMH on brain MRI in the healthy elderly after 1 and 3 years, and whether the number and location of CMH affects cognitive function.