Molecular Analysis, Modeling and Correction of Skin Diseases Core Center

描述（由申请人提供）：这是SDRC“皮肤病分子分析、建模和校正核心中心”的竞争性更新。这是科罗拉多大学安舒茨医学院（UCAMC）的一个基础广泛的项目，有56名成员，其中22名来自皮肤科。其目标是通过分子技术纠正人类皮肤疾病。该中心的前4年取得了巨大成功：国家发改委合作项目或P&F项目的研究人员为机构研究基地增加了20,371,611美元的新研究经费；P&F项目本身在头4年的投资回报率约为35倍。SDRC内的合作已经发表了71篇论文，这些论文得到了研究核心的大力支持。丰富的计划和合作的管理已经创建了一个强大的合作网络的研究人员在皮肤疾病相关的研究。在接下来的5年里，我们将把王晓兴加入到我们的领导团队中，该团队由David Norris、Dennis Roop和Richard Spritz组成。我们将保留5个核心（行政核心、分子遗传分析核心、生物工程核心、形态和表型核心以及流式细胞术核心），但所提供的服务将根据前4年的资助经验和咨询委员会的建议进行调整和加强。充实计划将通过创建：一个全球皮肤病研究联盟，以促进国际研究合作，加快新科学在令人兴奋的转化研究项目中的应用；一个指导计划“一个新技术计划，以促进ucam - sdrc和全球联盟的研究。临床研究小组新成员的加入，以及靠近SDRC成员实验室和AMC临床设施的新GMP设施的可用性，将极大地加强使用该SDRC开发的治疗方法的转化研究。

DESCRIPTION (provided by applicant): This is competing renewal of the SDRC "Molecular Analysis, Modeling and Correction of Skin Diseases Core Center". This is a broad based program on the University of Colorado Anschutz Medical Campus (UCAMC) with 56 members including 22 within the Department of Dermatology. Its goal is the correction of human skin diseases by molecular techniques. The first 4 years of this Center have been highly successful: SDRC investigators in collaborative projects or in P&F projects have added $20,371,611 in new research funding to the Institutional Research Base; The P&F program itself has shown a ~35-fold return on investment during the first 4 years. Collaborations within the SDRC have resulted in 71 published papers that were greatly supported by the Research Cores. The enrichment program and the management of collaborations have created a powerful collaborative network of investigators in skin disease related research. During the next 5 year period, we will add Xiao-Xing Wang to our leadership team of David Norris, Dennis Roop and Richard Spritz. We will retain 5 Cores (Administrative Core, Molecular Genetic Analysis Core, Bioengineering Core, Morphology and Phenotyping Core, and a Flow Cytometry Core), but the services offered will be altered and enhanced based on the experience of the first 4 years of funding, and on the suggestions of the Advisory Committee. The Enrichment Program will be greatly expanded by creating: A Global Skin Diseases Research Consortium to promote international research collaborations and speed the application of new science to exciting translational research projects A Mentorship Program "A New Technology Program to facilitate research within the UCAMC-SDRC and in the Global Consortium. Translational research using treatments developed by this SDRC will be greatly enhanced by addition of new members to the Clinical Investigations Team, and by the availability of a new GMP facility in close proximity to the SDRC member laboratories and clinical facilities on the AMC.