Bioinformatics/statistical support

摘要-核心B 概述/基本原理：核心B是新开发的，以满足整个计划范围内日益增长的复杂需求 癌症基因组学和生物信息学支持，以及对实验的统计支持的持续需要 设计和数据分析。这个核心的新开发的生物信息学/癌症基因组学部分增加了 为该计划提供大量的癌症基因组学专业知识。我们已经包括了对实验的持续支持 出于智力一致性和业务运作的原因，设计和统计支持核心B中的核心服务 效率。 创新：作为其服务计划的一部分，Core B开发了以下创新： ·通过可视化、热点分析和功能预测进行系统突变评估。 ·肿瘤和癌症亚型的综合评分，用于突变途径和癌症的投资 这是个标志。 ·大型图形基础设施和实施专业知识，可实现实时关联和 多维癌症基因组数据的可视化。 ·为实验设计和数据分析提供综合统计支持。 意义：癌症基因组研究在很大程度上依赖于数据挖掘和计算分析。 以最有效的方式执行这些分析需要合并大型数据集(例如，来自TCGA) 作为托管稳定和适当的分析工具的大量计算基础设施的一部分 专注于AML和GBM的计划研究项目将需要一种综合方法，将 通过对现有工具和方法的明智选择和富有想象力的使用，解释本地生成的数据。 核心B建立在这种模式之上，既是支持计划研究需求的一种有效而强大的方式。 核心B服务计划：核心B将提供以下6项关键服务，以支持整个计划的研究： 核心服务1-突变评估分析 核心服务2--关联分析 核心服务3-途径分析 核心服务4-突变投资分析 核心服务5-大型图表分析 核心服务6--统计支助 影响：Core B已汇集专业知识，全力支持生物信息学、癌症基因组学 以及全面启用所有项目研究计划所需的统计支助服务。

SUMMARY – Core B Overview/Rationale: Core B was newly developed to meet the growing Program-wide need for sophisticated cancer genomics and bioinformatics support, and the continuing need for statistical support for experimental design and data analysis. The newly developed bioinformatics/cancer genomics portion of this Core adds substantial cancer genomics expertise to the Program. We have included continuing support for experimental design and statistical support core services in Core B for reasons of intellectual coherence and operational efficiency. Innovation: Core B has developed the following innovations as part of their Service Plan: • Systematic mutation assessment by visualization, hotspot analysis and functional prediction. • Integrated scoring of tumors and cancer subtypes for mutational investment in pathways and cancer hallmarks. • Large graph infrastructure and implementation expertise to enable real-time association and visualization of multidimensional cancer genomics data. • Integrated statistical support for experimental design and data analysis. Significance: Cancer genomics research is heavily dependent on data mining and computational analysis. Performing these analyses in the most effective way requires incorporating large data sets (e.g., from TCGA) as part of a substantial computational infrastructure that hosts stable and appropriate tools for analysis Program research projects focusing on AML and GBM will require an integrated approach that blends and interprets locally-generated data by the judicious choice and imaginative use of existing tools and methods. Core B has been built on this model as both an efficient and powerful way to support Program research needs. Core B Services Plan: Core B will provide the following 6 key Services to enable research Program-wide: Core Service 1 – Mutation Assessment analyses Core Service 2 – Association analysis Core Service 3 – Pathway analysis Core Service 4 – Mutational Investment analyses Core Service 5 – Large graph analysis Core Service 6 – Statistical support IMPACT: Core B has assembled the expertise to fully support the combined bioinformatics, cancer genomics and statistical support services needed to fully enable all Project Research Plans.