The Female Urinary Microbiome: Adjacent Microbiomes and Clinical Associations

 描述（由申请人提供）：洛约拉泌尿教育和研究协作（LEUREC）是一个由临床医生，分子生物学家和计算科学家组成的多学科研究团队，他们在泌尿健康领域密切合作，在女性泌尿微生物组（FUM）及其与女性尿路上皮功能的相互作用方面具有特殊的专业知识。该P20应用程序的主要科学重点是 FUM与邻近阴道和会阴微生物组的关系，这些盆底微生物组与泌尿系统症状和临床结果的相关性，以及旨在使整个泌尿系统研究社区受益的泌尿系统微生物组数据库的启动。教育重点是交叉培训本科生，医学和研究生，临床医生，基础科学家，生物信息学家和生物统计学家在新兴的泌尿微生物领域。通过开始探索FUM的起源，并通过确定不同盆底微生物组与泌尿系统症状和临床结果之间的关联，我们预计拟议的研究将影响泌尿系统研究的广泛领域，特别是尿失禁，以及尿路感染和尿路疼痛疾病。目的是 先进的预防、临床诊断和治疗。

 DESCRIPTION (provided by applicant): The Loyola Urinary Education and REsearch Collaborative (LEUREC) is an established multidisciplinary research team consisting of clinicians, molecular biologists, and computational scientists that work closely in the area of urinary health, with special expertise in the female urinary microbiome (FUM) and its interactions with female urothelial function. The major scientific focus of this P20 application is the relationship of the FUM to the adjacent vaginal and perineal microbiomes, associations of these pelvic floor microbiomes with urinary symptoms and clinical outcomes, and initiation of a urologic microbiome database designed to benefit the entire urologic research community. The educational focus is to cross-train undergraduates, medical and graduate students, clinicians, basic scientists, bioinformaticians and biostatisticians in the emerging field of urinary microbiomics. By beginning exploration into the origins of the FUM, and by identifying associations between the different pelvic floor microbiomes and urinary symptoms and clinical outcomes, we expect the proposed study will impact broad areas of urinary research, especially urinary incontinence, but also urinary tract infection and urinary pain disorders. The intent is to advance prevention, clinical diagnosis and treatment.