Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)

描述（由申请人提供）：这是Claude D的竞争性续期申请。密歇根大学胡椒老年美国人独立中心（UM胡椒中心）。UM Pepper中心的具体目标是：1）支持研究，以提高对代谢因素和炎症如何与年龄相关疾病和合并症相互作用的理解，以确定与移动性和功能状态相关的关键健康结果。2)支持关于代谢因子和炎症与年龄相关疾病和合并症相互作用的转化研究，以改善与移动性和功能状态相关的健康结果。为了实现这一目标，UM Pepper中心将与其他UM项目密切合作，包括NIH资助的密歇根临床与健康研究所（MICHR），该研究所是UM临床与转化科学奖（CTSA）的所在地。3)提供资源核心，支持和协助与UM Pepper中心的研究重点相关的项目。4)通过其研究职业发展核心（RCDC），加强UM环境，培养未来的老年医学和老龄化学术领袖，他们可以进行与UM Pepper中心研究重点相关的研究。5)通过其试点和探索性研究核心（PESC），吸引UM初级教师，以及选定的高级教师以前没有参与老龄化研究，开发与UM辣椒中心的研究重点有关的新的研究项目。UM胡椒中心，现在在其连续NIA资助的第25个年头，有一个完善的领导和行政结构，一个RCDC，一个PESC和四个RC：人类受试者和评估核心（HSAC）;生物力学核心（BC）;方法，数据管理和分析核心（MDMAC）;和老年啮齿动物核心设施（CFAR）。RCDC有三个核心要素：1）竞争性计划，每年选择2名有前途的UM初级教师进行与UM Pepper中心研究重点相关的研究，使用KL 2机制，以保证75%的研究职业发展努力; 2）为从事此类研究的初级教师提供国家认可的研究培训计划，以及3）导师计划，增加初级教师与一名或多名UM高级调查员密切合作的机会。通过严格的外部审查，PESC每年将资助4个或更多的试点项目。RC将支持多个外部资助的项目，胡椒中心试点赠款和RCDC初级教师，并继续开发和测试新的方法用于胡椒中心的研究。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center is: 1) to support research that will improve understanding of how metabolic factors and inflammation interact with age related diseases and comorbidities to determine key health outcomes related to mobility and functional status. 2) To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve this aim, the UM Pepper Center will work closely with other UM programs including the NIH funded Michigan Institute for Clinical and Health Research (MICHR), the home of the UM's Clinical and Translational Science Award (CTSA). 3) To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center's research focus. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center's research focus. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty, as well as selected senior faculty not previously involved in aging research, to develop new research projects related to the UM Pepper Center's research focus. The UM Pepper Center, now in its 25th year of continuous NIA funding, has in place a well-established leadership and administrative structure, an RCDC, a PESC, and four RCs: the Human Subjects and Assessment Core (HSAC); the Biomechanics Core (BC); the Methodology, Data Management and Analysis Core (MDMAC); and the Core Facility for Aged Rodents(CFAR). The RCDC features three central elements: 1) a competitive program to select 2 promising UM junior faculty per year to conduct research relevant to the UM Pepper Center's research focus using the KL2mechanism to guarantee 75% effort for research career development; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC, through rigorous external review, will fund 4 or more pilot projects per year. The RC's will support multiple externally funded projects, the Pepper Center pilot grants and RCDC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.