Alteration and Renovation

项目摘要 有效和高效的大型化学库的高通量筛选(HTS)需要许多仔细的 协调努力，从目标选择到化验验证，再到自动化的大规模 放映。此外，测试开发和进行传染病的高通量筛查 由于生物危害和遏制问题，目标往往需要特殊考虑和条件。 为这些特殊考虑事项做好准备，并尽量减少感染性病原体对一般人的影响 由于高温超导设施和相关设备的活动，我们建议翻新毗邻高架的空间- 吞吐量筛查设备，以使其适合于执行传染病检测开发和 与B核心有关的有限化学筛选。拟议的翻修工程将提供211平方英尺的 专门用于传染病检测开发和许多高通量筛查的实验室空间 程序。拟议中的实验室将通过来自 堪萨斯大学。翻新的时间估计在六个月内完成。 资金的收款。

Project Summary Effective and efficient high-throughput screening (HTS) of large chemical libraries requires many carefully coordinated efforts that span target selection through assay validation and into automated large-scale screening. Additionally, assay development and performing high-throughput screening for infectious disease targets can often require special consideration and conditions due to biological hazard and containment issues. To provide for these special considerations and minimize the impact of infectious agents on the general activities of the HTS facility and associated equipment, we propose to renovate space adjacent to the high- throughput screening facility such that it is suitable for performing infectious disease assay development and limited chemical screening associated with Core B. The proposed renovations would provide 211 sq ft of laboratory space dedicated for infectious disease assay development and many high-throughput screening procedures. The proposed laboratory would be suitably equipped through direct contributions from the University of Kansas. Timing for renovations to be completed are estimated to be within six months after receipt of funds.