Animal Shared Resource

动物共享资源-项目摘要/摘要 动物共享资源为CSHL癌症中心成员提供完整的支持 高质量的动物住房、畜牧服务以及技术和管理支持，以涵盖以下各方面 动物护理和使用，如组织活检、群体管理和协议执行。此外, 训练有素的人员向研究人员传授各种专业技能，包括外科操作和 术后监测，血液和组织采集，剖宫产再手术，组织灌流，以及 治疗和病毒管理。动物共享资源的兽医技能使研究人员能够 产生新的和创新的小鼠癌症模型，包括病毒转导模型，多等位基因 可逆性肿瘤模型和人、鼠肿瘤器官类原位移植模型。 此外，动物共享资源开发并提供实施新动物的培训 协议。动物共享资源提供的支持对许多研究来说是绝对基础的 CSHL癌症中心的进展。它使研究人员能够开发出创新的动物模型 癌症继续在揭示这种疾病的遗传和分子基础方面发挥着重要作用。作为 CSHL癌症中心转移扩大其临床前和翻译研究，动物模型将成为 更重要的是。动物共享资源使研究人员能够超越细胞培养，并 在适当的活体环境中探索癌症生物学和癌症医学。总而言之，动物分享了 资源为癌症中心提供一整套基本服务和复杂的技术 支持促进癌症研究和发现。五年来，共有27家癌症中心 成员(73%的成员)使用动物共享资源，占设施的大部分 使用。这一共享资源在这段时间内促成了癌症中心成员发表的70篇文章。

Animal Shared Resource - Project Summary/Abstract The Animal Shared Resource offers integral support to CSHL Cancer Center members by providing high quality animal housing, husbandry services, and technical and managerial support to cover all aspects of animal care and use such as tissue biopsies, colony management and protocol implementation. In addition, highly trained personnel teach a variety of specialty skills to researchers, including surgical manipulations and post surgery monitoring, blood and tissue procurement, cesarean re-derivation, tissue perfusion, and therapeutic and virus administration. The veterinary skills of the Animal Shared Resource enable researchers to generate new and innovative mouse cancer models including viral transduction models, multi-allele reversible cancer models, and organoid orthotopic engraftment models of human and mouse cancer. Furthermore, the Animal Shared Resource develops and provides training for implementing new animal protocols. The support provided by the Animal Shared Resource is absolutely fundamental for many research advances in the CSHL Cancer Center. It has enabled researchers to develop innovative animal models for cancer, which continue to be instrumental in uncovering the genetic and molecular basis of the disease. As the CSHL Cancer Center shifts to expand its preclinical and translational research, animal models will become even more important. The Animal Shared Resource enables researchers to move beyond cell culture and to explore cancer biology and cancer medicine in an appropriate in vivo context. In summary, the Animal Shared Resource provides the Cancer Center with a complete set of essential services and sophisticated technical support to facilitate cancer research and discovery. Over the past five years, a total of 27 Cancer Center members (73% of members) utilized the Animal Shared Resource, representing the majority of the facility's use. This Shared Resource contributed to 70 publications by Cancer Center members over this time period.