Biostatistics and Bioinformatics Shared Resource

生物统计学和生物信息学共享资源 项目摘要/摘要 Winship生物统计和生物信息学共享资源(BBISR)在以下方面提供服务和协作 临床、实验室、人群和分子癌症研究设计和分析。BBISR由一个团队定义- 基于支持癌症研究人员的方法，其中BBISR教职员工深思熟虑地参与到 获得准确的结果，同时意识到他们在这项癌症研究中的作用和 他们被处死。BBISR的总体目标是为Winship的 基础研究、转化研究和临床研究。这是通过确保使用适当的研究设计来实现的 以及Winship成员为他们的研究项目提供的分析方法。BBISR已经建立了一个用户友好的 在线服务请求系统，允许及时支持和跟踪SR利用率，并利用现有 埃默里大学的专业知识，以满足Winship成员的需求。它专门为Winship研究人员提供支持 通过：设计试验，注意可行性、样本量和生物标记物分析；数据分析和 编写研究总结报告；协助编写与统计有关的章节的手稿 设计和方法；以及在Winship的临床和翻译研究委员会上对提案的审查 (CTRC)。BBISR的工作人员被整合到Winship的研究计划和整个埃默里 大学，包括罗林斯公共卫生学院。BBISR的工作人员和教职员工拥有丰富的专业知识 在第一阶段临床试验设计、回溯性研究设计和分析、临床生物信息学、路径和 分子和癌症监测形式的网络分析、融合分析和大数据分析 数据。BBISR支持了几种高影响力的出版物，并在所有团队科学项目中发挥了关键作用 在这一资助期间，在Winship进行了一些项目。BBISR支持Winship Team科学项目 包括头颈部癌症孢子，肺癌的计划项目申请(重新提交 2016年9月)，正在开发的肺癌孢子申请(将于2016年9月提交)，以及 机构临床试验，包括第一阶段研究。此外，BBISR成员进行的原创研究 在设计和进行I期临床试验方面取得了重要的方法学进步。总的来说， 在此资助期间，BBISR在Winship项目中支持了115名核心调查人员，这些合作 产生了216种出版物和50笔同行评议赠款。BBISR的利用率稳步增长 在目前的资助期内，所有四个Winship计划的成员和BBISR都处于有利地位 支持Winship正在进行和计划中的研究项目。

BIOSTATISTICAL AND BIOINFORMATICS SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Winship Biostatistics and Bioinformatics Shared Resource (BBISR) offers services and collaboration in clinical, laboratory, population, and molecular cancer study design and analysis. BBISR is defined by a TEAM- based approach to support cancer investigators, in which BBISR faculty and staff are Thoughtfully Engaged to obtain Accurate results, while being Mindfully aware of their role in this cancer research and the deadlines for their execution. The overall goal of BBISR is to provide outstanding statistical and analytical support to Winship's basic, translational, and clinical research. This is accomplished by ensuring the use of appropriate study design and analytical methods by Winship members for their research projects. BBISR has established a user-friendly online service request system that allows for timely support and tracking of SR utilization, and leverages existing Emory University-wide expertise to meet Winship member needs. It supports Winship researchers specifically by: designing trials with attention to feasibility, sample size, and biomarker analysis; data analysis and preparation of study summary reports; assistance with manuscript preparation for sections relevant to statistical design and methods; and review of proposals in Winship's Clinical and Translational Research Committee (CTRC). BBISR staff members are integrated within Winship's research programs and throughout Emory University, including the Rollins School of Public Health. BBISR staff and faculty members have strong expertise in phase I clinical trial designs, retrospective study designs and analysis, clinical bioinformatics, pathways and network analysis, fusion analysis, and analysis of “Big Data” in the form of both molecular and cancer surveillance data. BBISR has supported several high-impact publications and played key roles in all the team-science projects that have been conducted at Winship during this funding period. BBISR supported Winship team science projects including the Head and Neck Cancer SPORE, a program project application for lung cancer (resubmission in September 2016), a developing Lung Cancer SPORE application (to be submitted in September 2016), and institutional clinical trials, including phase I studies. In addition, original research conducted by BBISR members have resulted in important methodological advances in the design and conduct of phase I clinical trials. Overall, BBISR supported 115 core investigators in Winship programs during this funding period, collaborations which have resulted in 216 publications and 50 peer-reviewed grants funded. Utilization of BBISR has grown steadily over the present funding period by membership of all four Winship programs and BBISR is well positioned to support Winship's ongoing and planned research projects.