UCSF Core Center for Musculoskeletal Biology and Medicine

描述（由申请人提供）：拟议中的UCSF医学肌肉骨骼生物学核心中心（CCMBM）将是一个由39名基础和临床科学家组成的跨学科联盟，致力于了解肌肉骨骼疾病的生物学和病理生理学。其目标是促进和支持UCSF现有的主要研究项目之间的跨学科合作，以加速骨质疏松症和骨关节炎的转化研究。从实验室到床边的转化研究的一个基本挑战是需要在人类身上验证小动物模型的发现。拟议的CCMBM将通过在研究疾病生物学的科学家、分析大量临床数据档案的研究人员和积极治疗患者的从业人员之间建立联系来克服这一障碍。UCSF CCMBM提出了三个核心：1)骨骼生物学核心；2)肌肉骨骼和定量成像核心；3)流行病学与生物统计学核心。这些核心将提供研究支持和技术培训，以及开展新合作的场所和新成员的切入点。该中心还将通过一项浓缩计划促进科学交流；课程包括每月一次以本地和访问科学家为主题的研讨会，每年一次与外部顾问委员会进行一整天的静修，以及每季度半天的与骨质疏松症和骨关节炎相关的轮换主题的研讨会。该中心的另一个重要组成部分是其试点/可行性计划。这为初级研究人员和刚从事肌肉骨骼研究的科学家提供了种子资金。最后，工具和技术资助计划将为中心成员提供资金，用于利用UCSF CCMBM之外的优秀专业研究服务。总的来说，拟议的CCMBM的资金基础是强大的，加州大学旧金山分校的支持是强大的，并且中心内外的互动机会很多。该中心的目标是充分利用所有可用资源，促进肌肉骨骼疾病基础生物学的发现。

DESCRIPTION (provided by applicant): The proposed UCSF Core Center for Musculoskeletal Biology in Medicine (CCMBM) will be an interdisciplinary consortium of thirty-nine basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in osteoporosis and osteoarthritis. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between scientists who study disease biology, researchers who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology Core; 2) Musculoskeletal and Quantitative Imaging Core; and 3) Epidemiology and Biostatistics Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes a monthly seminar featuring local and visiting scientists, an annual full-day retreat with the External Advisory board, and a quarterly half-day symposium with a rotating topic relevant to osteoporosis and osteoarthritis. Another vital component of the Center is its Pilot/Feasibility Program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology Grant Program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the proposed CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.