New Ionization Technique for MS Imaging

 描述(申请人提供)：基质辅助激光解吸电离(MALDI)方法效率的显著提高和无损亚大气压界面在质谱仪(MS)中的使用将对基于MS的组织成像和整个蛋白质、脂类和代谢物表征的分析领域产生深远影响建议提高MALDI源的电离效率将使其成为研究实验室和临床环境中不可或缺的工具。我们计划建立一个结合大气MALDI源和非常高效的离子收集器的平台，以显著提高从组织中采集的微量生物材料的MS分析的灵敏度和速度。

 DESCRIPTION (provided by applicant): Significant increase in the efficiency of matrix assisted laser desorption ionization (MALDI) method and utilization of lossless sub-atmospheric pressure interface in mass spectrometry (MS) will have a profound impact on MS-based tissue imaging and on the entire analytical field of characterization of proteins, lipids, and metabolites Proposed increase in ionization efficiency of MALDI sources will make it an indispensable tool for both research laboratories and in clinical settings. We plan to build a platform combining atmospheric MALDI source and very efficient ion collector to drastically improve sensitivity and speed of MS-based analysis of miniscule amount of biomaterials harvested from tissues.