Augmenting Endoscopic Instruments with Real-time 3D Imaging

项目总结： 衰老会增加患胃肠道疾病的风险，如结直肠癌、炎症性肠病和 阑尾炎。NIH的统计数据显示，有6000万至7000万人受到消化系统疾病的影响。 不断增加的全球老年人口基数预计将在未来进一步恶化这种情况 好几年了。每年，胃肠道疾病(GI)就诊人数超过3000万人次 仅在美国就有1000多万例胃肠道内窥镜检查 消化道，包括食道、胃、小肠、结肠和直肠。微创 外科(MIS)内窥镜仍被用作主流，市场需求接近100亿美元 诊断性和治疗性临床手术的增长率接近两位数。 遗憾的是，现有的基于视频的内窥镜只能提供2D图像用于视觉检查 仅出于目的，它不能提供关于体积、面积和位置的3D定量信息 疾病，以及诊断和治疗设备的相对位置。要解决这个问题 问题，Xyken和它的合作者提议开发一种新的成像系统来提供 胃肠道解剖结构的2D/3D摄像。拟议的软件系统将具有以下功能 临床影响和意义： 通过量化的方式极大地促进了诊断、规划和治疗过程 评估、准确的深度感知和更安全的导航 通过活体3D数字为住院医师/医生提供更有效的临床培训方法 胃肠道模型 有可能取代基于CT的图像引导手术--消除辐射和配准 导致的错误 已发表的研究报告发现，在慢性病患者数量增加的推动下 人口和老龄化，全球内窥镜设备市场预计到 2020年为238亿美元，年复合增长率为6.1%。随着人口老龄化和城市化进程的加快 在新兴经济体中，全球需求预计将以更快的速度增长。这个 因此，拟议系统的商业化潜力和经济影响是巨大的。

Project Summary: Aging increases the risk of GI disorders such as CRC, inflammatory bowel disease, and appendicitis. NIH statistic shows that 60 to 70 million people are affected by digestive diseases. Increasing global geriatric population base is expected to further worsen this situation over the coming years. Annually, diseases of the gastrointestinal (GI) tract account for more than 30 million office visits and more than 10 million GI endoscopic procedures in the United States alone for the examinations of digestive tract including the esophagus, stomach, small intestine, colon, and rectum. Minimally Invasive Surgery (MIS) endoscopes are still utilized as the main stream with close to $10 billon market needs and near double digit growth rate for performing both diagnosis and therapeutic clinic operations. Unfortunately, existing video based endoscopes can only provide 2D images for visual inspection purpose only, it cannot provide 3D quantitative information on volume and area and location of the disease, as well as the relative position of diagnostic and therapeutic equipment. To address this problem, Xyken together with its collaborator proposes to develop a novel imaging system to provide 2D/3D videoing of the GI anatomical structure. The proposed software system will have the following clinic impact and significance:  Greatly facilitating the diagnosis, planning, and treatment process through quantitative assessment, accurate depth perception and safer navigation  Providing more effective clinical training method for residents/doctors through in-vivo 3D digital GI tract model  Potentially replacing CT based image guided surgery – eliminating radiation and registration caused errors Published research reports find that, driven by the increasing number of the chronically ill population and aging, the global endoscopy equipment market is expected to reach USD 33.6 Billion by 2020 from USD 23.8 Billion in 2015, at a CAGR of 6.1%. With the aging population and advancement of the emerging economies, the global demand is expected to grow with an increased rate. The commercialization potential and economic impact of the proposed system is thus significant.