Core B: Training Core

项目总结/摘要 MDCRC培训核心的总体目标是严格增加 受过训练和有科学能力的研究人员能够维持生产性的基础科学， 转译和/或临床研究项目。为了满足这个中央 目标核心将确定和招募合格的基础科学和临床博士前， 博士后候选人谁表现出真正的兴趣，并有潜力，独立 基础科学、转化和/或临床研究。培训核心将 部分支持一名博士前实习生在加州大学洛杉矶分校，与支持资金从加州大学洛杉矶分校毕业生 司和CureDuchenne，并在用友博士后实习生，从用友的支持资金 医学院。此外，医学的UF学院将提供资金，以支持无论是 博士前或博士后实习生的补助金和公共UF学院的持续时间 健康与健康奖学金将在资助期间支持博士前实习生。到 有资格获得博士前实习生职位，申请人必须在资格之外取得进展 考试，并致力于论文实验室。UF神经肌肉可塑性T32训练 该计划还将分配其六个博士前实习生名额之一，以一个合适的候选人工作 在一个以肌肉萎缩症为中心的实验室里。此外，肌营养不良家长项目将支持 每年一名临床实习生的部分工作，从任何中心地点选择。因此，在本发明中， 总共3或4名博士预科生，1或2名博士后和1名临床实习生将得到支持， 直接由培训核心、支持机构基金或现有培训计划提供。 除T32计划外，这些职位的受训人员将获得一段时间的支持， 至2年。此外，加州大学洛杉矶分校也有一个肌肉细胞生物学的申请， 发病机制和治疗T32培训计划。如果获得资助，该计划将为 肌肉萎缩症的博士前和博士后学员。 在UF和加州大学洛杉矶分校的培训核心将监督和协调一系列正式和 为所有这些受训人员以及博士前、博士后和 在研究人员的实验室从事肌营养不良研究的临床研究人员 通过MDCRC的项目提供支持。每个学员将准备一个个人 根据他们过去的培训和他们的建议，使用MyIDP制定发展计划。 主要导师和论文委员会。根据受训者的职业阶段 （博士前，博士后或临床研究员），个性化计划可能包括结构化的 教学计划，包括研究方法，专业课程和研讨会，以及 指导赠款写作经验。 培训核心将通过支持1）年度 学员在佛罗里达大学和加州大学洛杉矶分校主持研讨会，2）前往参加年度全国儿童 医院/俄勒冈州立大学/Wellstone肌肉学课程，对于参加课程的人， 为来自UF，UCLA和NU的学员举办演讲晚会，3）前往我们的 Wellstone中心在肌肉生物学和疾病国际会议上调整了新方向。 此外，重要的是，培训核心将努力使具体的课程内容， 肌肉疾病为中心的课程，从每个机构提供在线为社区。

Project Summary/Abstract The overall objective of the MDCRC Training Core is to increase the number of rigorously trained and scientifically competent researchers capable of sustaining productive basic science, translational and/or clinical research programs in muscular dystrophy. To meet this central objective the core will identify and recruit qualified basic science and clinical predoctoral and postdoctoral candidates who demonstrate a genuine interest in, and potential for, independent basic science, translational and/or clinical research in muscular dystrophy. The training core will partially support one predoctoral trainee at UCLA, with supporting funds from UCLA Graduate Division and CureDuchenne, and one postdoctoral trainee at UF, with supporting funds from UF College of Medicine. In addition, the UF College of Medicine will provide funds to support either a predoctoral or postdoctoral trainee for the duration of the grant and the UF College of Public Health & Health Professions will support a predoctoral trainee for the duration of the grant. To be eligible for predoctoral trainee slots, applicants must have progressed beyond their qualifying exam and have committed to a thesis laboratory. The UF Neuromuscular Plasticity T32 Training Program will also allocate one of its six predoctoral trainee slots to a suitable candidate working in a muscular dystrophy-centered lab. Further, Parent Project Muscular Dystrophy will support the partial effort of one clinical trainee per year, to be chosen from any of the center sites. Thus, overall 3 or 4 predoctoral, 1 or 2 postdoctoral and 1 clinical trainee will be supported either directly by the training core, supporting institutional funds, or existing training programs. Trainees in each of these positions, except the T32 program, will be supported for a period of up to 2 years. In addition, UCLA also has an application pending for a Muscle Cell Biology, Pathogenesis and Therapies T32 Training Program. If funded, this program will provide slots for both pre- and postdoctoral trainees in muscular dystrophy. The Training Cores at UF and UCLA will oversee and coordinate a spectrum of formal and informal training activities for all of these trainees, as well as the predoctoral, postdoctoral and clinical fellow researchers engaged in muscular dystrophy research in the labs of researchers supported through the projects of the MDCRC. Each trainee will prepare an Individual Development Plan using MyIDP, based on their past training and recommendations from their primary mentor and thesis committee. Depending on the career stage of the trainee (predoctoral, postdoctoral or clinical fellow), the individualized plan may consist of a structured didactic program involving research methodology, specialized courses and seminars, and mentored grant writing experiences. The Training Cores will further enhance the training environment by supporting 1) annual trainee hosted seminars at UF and UCLA, 2) travel to attend the Annual Nationwide Children’s Hospital/OSU/Wellstone Myology Course and, for those attending the course, a trainee presentation evening for trainees from UF, UCLA and NU and, 3) travel to present at our Wellstone Center aligned New Directions in Muscle Biology and Disease international meeting. In addition, and importantly, the Training Cores will work to make specific course content from muscle disease centered courses from each institution available on-line for the community.