Toward A Macaque Model Of Social Brain Dysfunction In Real-Life Social Interactions

项目摘要 我们的计划将研究内侧额叶皮质(MFC)和 杏仁基底外侧核(BLA)参与复杂的社会相互作用。我们将利用我们最新的 在成对恒河猴中发展了社会凝视交互范式，以了解神经生物学 MFC-BLA偶联的机制，目标是致力于产生一个猕猴社会模型 功能障碍。我们将首先确定这两个地区是否以及如何在各种社会活动中进行协调 凝视事件(例如，看着眼睛或相互的眼神交流)。然后我们将按顺序刺激MFC和/或BLA 破坏MFC-BLA的协调，导致社会凝视缺陷。最后，我们将检查这些 通过测试干扰MFC-BLA协调的影响，可以将干扰推广到其他社交领域 在一个复杂的社会决策博弈中。从这些结果得知，我们希望在未来调查如何 药理学(系统性或局部性药物操作)和行为(社会互动操作) 干预可以有效地恢复可诱导的社会赤字。

Project Summary Our proposal will investigate how neuronal coordination between the medial frontal cortex (MFC) and the basolateral amygdala (BLA) is causally involved in complex social interactions. We will capitalize on our newly developed social gaze interaction paradigm in pairs of rhesus macaques to understand the neurobiological mechanisms of MFC-BLA coupling, with a goal of working toward generating a macaque model of social dysfunction. We will first determine whether and how the two regions are coordinated during various social gaze events (e.g., looking at the eyes or mutual eye contact). We will then stimulate MFC, BLA or both in order to disrupt the MFC-BLA coordination to induce social gaze deficits. Finally, we will examine whether these disruptions are generalizable to other social domains by testing the impact of perturbing MFC-BLA coordination in a complex social decision-making game. Informed by these results, we hope to investigate in the future how pharmacological (systemic or focal drug manipulations) and behavioral (social interaction manipulations) interventions could effectively restore the inducible social deficits.