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中文摘要
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项目摘要/摘要-教育核心 __________________________________________________________________________ 扩展基因组诊断工具并实现病毒测序、临床和宿主 在西非进行基因组研究,我们需要在以下方面建立长期能力和科学专长 我们相互关联的研究项目的所有参与站点。我们的一个主要组成部分 因此,合作的中心将是基因组学、生物信息学和生物统计学的转移 向非洲科学家提供知识,以促进和促进该区域#年的科学项目 为了实现这一目标,我们与来自美国的同事合作开发了一系列 教育讲习班和研究生课程,以加强非洲的研究能力和 促进以基因组学为基础的尖端研究和科学事业,这与我们的 研究努力(项目1-3)。ACEGID的旗舰教育企业是年度 夏季基因组学培训计划由哈佛大学萨贝蒂实验室和 博德学院。我们的培训计划传授与利用基因组学为 非洲传染病的诊断和深入的病原体研究。以前的工作有 使我们处于有利地位,可以将我们的面对面培训计划扩展到H3非洲财团 以及开发一个强大的、全球可访问的实用基因组学在线培训课程 用于传染病的诊断。为此,我们将加强和扩大我们的 为我们的协作中心和H3非洲提供现有的年度面对面基因组学培训 联盟学生,使毕业生能够使用这些材料在 他们的祖国。在这个项目中,我们还将把我们的培训材料转化为更广泛的 通过生成关于实践的大规模开放在线课程(MOOC)来分发和在线访问 传染病基因组学培训,并扩大我们现有的外展方案 向社会传播研究成果和新的基因组学信息。这个 因此,教育核心支撑了我们协作中心的总体目标,将愿景和 物流是项目成功的保障,是新转移的实用机制 为非洲开发了计算方法、病毒测序和诊断技术 科学家。
英文摘要
Project Summary/Abstract - Education Core __________________________________________________________________________ To expand genomic diagnostic tools as well as enable viral sequencing, clinical, and host genomic research in West Africa, we need to build long-term capacity and scientific expertise at all participating sites for our interconnected research projects. A major component of our collaborative center will therefore be the transfer of genomics, bioinformatics and biostatistical knowledge to African scientists to promote and facilitate scientific projects in the region in collaboration with colleagues from the U.S. To accomplish this we have developed a series of educational workshops and graduate-level curricula to enhance African research capacity and foster cutting-edge genomics-based research and science careers, which complement our research efforts (Projects 1-3). The flagship educational enterprise of ACEGID is the annual summer genomics training program hosted by the Sabeti Lab at Harvard University and the Broad Institute. Our training program imparts specific skills related to utilizing genomics for the diagnosis of infectious disease and in-depth pathogen research in Africa. Previous work has placed us well positioned to expand our in-person training program to the H3Africa consortium as well as develop a robust, globally accessible, online training curriculum of practical genomics for diagnostics of infectious diseases. Towards this objective, we will enhance and expand our existing annual in-person genomics training for our collaborative center and H3Africa consortium students, enabling graduates to use these materials to conduct training courses in their home countries. During this project, we will also convert our training materials for wider distribution and online access by generating a massive open online course (MOOC) on practical training for genomics of infectious disease, and expand upon our existing outreach programme to disseminate research outcomes and new genomics information to the community. The Educational Core thus underpins our collaborative center’s overall aims, bridging vision and logistics to ensure the project’s success, and is the practical mechanism to transfer newly developed computational approaches, viral sequencing, and diagnostic technologies to African scientists.
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Comprehensive functional characterization and dissection of noncoding regulatory elements and human genetic variation
  • 批准号:
    10241056
  • 项目类别:
  • 资助金额:
    $149.63万
  • 财政年份:
    2017
  • 负责人:
    Pardis Christine Sabeti
  • 依托单位:
Comprehensive functional characterization and dissection of noncoding regulatory elements and human genetic variation
  • 批准号:
    9766882
  • 项目类别:
  • 资助金额:
    $149.77万
  • 财政年份:
    2017
  • 负责人:
    Pardis Christine Sabeti
  • 依托单位:
Comprehensive functional characterization and dissection of noncoding regulatory elements and human genetic variation
  • 批准号:
    9247640
  • 项目类别:
  • 资助金额:
    $65.4万
  • 财政年份:
    2017
  • 负责人:
    Pardis Christine Sabeti
  • 依托单位:
Project 1 Viral Genomics: surveillance, epidemiology, host response, and viral immunogenicity
  • 批准号:
    10163684
  • 项目类别:
  • 资助金额:
    $35.0万
  • 财政年份:
    2014
  • 负责人:
    Pardis Christine Sabeti
  • 依托单位:
海外基金