PRIDE: Functional and Translational Genomics of Blood Disorders

 描述(由申请人提供)：我们今天在医疗保健领域面临的最重要的挑战之一是美国生物医学研究队伍缺乏多样性。为了解决这个问题，2006年，国家心肺血液研究所(NHLBI)资助了夏季研究所增加多样性(SIPID)培训计划，后来又资助了参与健康相关研究的个人增加多样性计划(PROID)。我们是这两个创新项目的创始成员，目前佐治亚州摄政大学(GRU)的血液疾病功能和应用基因组学夏季研究所正处于最后一年。我们招募并培训了47名初级教员导师，他们接受了密集的指导，包括板凳研究和资质方面的实践培训。计划评估表明，这些暑期学院已经实现了他们的主要目标，即在计划完成后两年内帮助受训者获得外部赠款资金。更新的GRU-PROID计划将保留以前计划的所有成功要素，同时对课程和指导活动进行几项创新。在此次续签期间，我们计划的目标将是通过密集的指导和实际操作的长椅研究培训经验，使36名指导者能够开发出具有竞争力的研究项目；该计划的成功将在一定程度上取决于每个指导者在计划完成后两年内获得外部资金的能力。为实现这一目标，我们提出了以下目标：目标1举办GRU PRORD 1暑期学院：GRU PROY 1暑期学院的实施工作，包括与协调核心合作建立个人指导委员会，将在该奖项的第一年开始。暑期研究所由多学科教学课程、实际操作的板凳研究培训和赠款撰写研讨会组成，以扩大学员在基因组研究领域的知识基础，因为基因组研究适用于血液疾病。目标2辅导和联网活动：除了继续保留我们的辅导委员会外，我们还将实施两项创新：学员虚拟网络和同伴联网实验室。受训者将在年中访问导师所在的机构，以完善他们的研究项目、拨款撰写技能、职业规划和板凳培训技术。目标3举办PARE 2暑期学院：学员将参加PARE 2暑期学院，以提供额外的功能和翻译基因组研究培训，并提高他们的赠款撰写技能。每个被辅导者将被要求提交一份赠款申请，以获得NHLBI赞助或其他外部资金。GRU-PROID方案的课程和学员的成功将与国家协调核心合作持续进行评估。

 DESCRIPTION (provided by applicant): One of the most important challenges we face in healthcare today is a lack of diversity in the US biomedical research workforce. To address this issue, in 2006 the National Heart Lung and Blood Institute (NHLBI) funded a Summer Institute Program to Increase Diversity (SIPID) training program, and later the Program to Increase Diversity Among Individuals Engaged in Health-Related Research (PRIDE). We were founding members of both innovative programs, with the Functional and Applied Genomics of Blood Disorders Summer Institute currently in its last year at Georgia Regents University (GRU). We recruited and trained 47 junior faculty mentees who received intense mentoring, including hands-on training in bench research and grantsmanship. Program evaluations suggest these Summer Institutes have achieved their primary goal of aiding mentees in obtaining extramural grant funding within two years of program completion. The renewed GRU-PRIDE program will keep all of the successful elements of the previous program, while offering several innovative changes to the curriculum and mentoring activities. The goal of our program during this renewal will be to empower 36 mentees to develop a competitive research project through an intensive mentoring and hands-on bench research training experience; success of this program will be measured, in part, by the ability of each mentee to acquire extramural funding within two years following program completion. To reach this goal we propose the following aims: AIM 1 Conduct GRU PRIDE 1 Summer Institute: implementation of the GRU PRIDE 1 Summer Institute, including the establishment of individual Mentorship Committees in collaboration with the Coordination Core will begin during the first year of this award. The Summer Institute is composed of a multidisciplinary didactic curriculum, hands-on bench research training and a grant-writing workshop to expand the knowledge base of mentees in the field of genomics research as it applies to blood disorders. AIM 2 Mentoring and Networking Activity: In addition to the continuation of our Mentorship Committees, we will implement two innovations: a mentee virtual network and a peer- networking laboratory. Mentees will make a mid-year visit to the mentor's institution to refine their research project, grant-writing skills, career planning, and bench training techniques. AIM 3 Conduct PRIDE 2 Summer Institute: Mentees will participate in the PRIDE 2 Summer Institute to provide additional functional and translational genomics research training and to improve their grant-writing skills. Each mentee will be required to submit a grant application to acquire NHLBI-sponsored or other extramural funding. The GRU-PRIDE program curriculum and mentee success will be evaluated continuously in collaboration with the national Coordination Core.