Integrated Endocrine and Metabolic Research Training

 描述(由申请人提供)：贝丝以色列女执事医学中心的内分泌培训计划，由Barbara Kahn博士指导，培训内分泌学、糖尿病和新陈代谢研究领域的医学博士、医学博士/博士和博士后候选人。该计划的目标是将受训人员培养成独立的调查人员，他们将在科学调查方面出类拔萃，并成功获得主要大学医学院的教职。第二个目标是为将继续从事临床医生-教育工作者职业生涯的研究员提供严格的科学基础。内分泌项目的研究人员是一群经验丰富的研究人员，他们都是哈佛医学院的教员，参与了肥胖症、糖尿病、“代谢综合征”、甲状腺生理学、甲状腺激素作用、核受体作用、神经内分泌学和信号转导的综合研究。该学院由基础科学家和临床科学家组成，他们共同努力培训研究员在分子和生理层面上调查研究问题。作为波士顿地区NIH资助的营养肥胖研究中心和糖尿病内分泌研究中心的一部分，多份联合出版物和共享的研究核心设施证明了教师的合作性质。受训者有机会学习教师在激素作用、基因表达调控、脂肪细胞生物学、动物生理学、内分泌和代谢障碍的先进转基因和基因靶向方法、神经解剖学和神经生理学、人体研究以及新治疗方式策略等领域的集体专业知识。我们的实习生在获得独立资助和晋升教员职位方面有着出色的记录。这些资助的研究人员现在参加内分泌学、糖尿病和新陈代谢方面的这一项目和其他项目的研究员培训。自上次竞争性续期以来，该司增加了新的有才华的教员，并扩大了其研究空间和核心设施。特别是，该计划得到了贝丝以色列女执事医疗中心在基因组学、蛋白质组学、代谢组学、质谱学、流式细胞术、生物统计学和生物信息学以及转基因小鼠生成方面的核心设施的大力支持。该项目进一步将其负责任的研究行为课程正规化。学员的成功反映了这一内分泌培训计划的卓越质量。

 DESCRIPTION (provided by applicant): The Endocrine Training Program at Beth Israel Deaconess Medical Center, directed by Dr. Barbara Kahn, trains MD, MD/PhD and PhD postdoctoral candidates in research areas of endocrinology, diabetes, and metabolism. The goal of the program is to foster the development of trainees into independent investigators who will excel in scientific investigation and succeed in obtaining faculty positions in major universiy medical schools. A secondary goal is to provide a rigorous scientific foundation for fellows who will go on to careers as clinician-educators. The research faculty for the endocrine program is an experienced group of investigators, all of whom are Harvard Medical School faculty members involved in the comprehensive study of obesity, diabetes, "the metabolic syndrome", thyroid physiology, thyroid hormone action, nuclear receptor action, neuroendocrinology and signal transduction. The faculty is comprised of basic scientists and clinical scientists who work together to train fellows to investigate research questions at the molecular and physiological levels. The collaborative nature of the faculty is evidenced by multiple joint publications and shared research core facilities as part of the Boston area NIH-funded Nutrition-Obesity Research Centers and Diabetes Endocrinology Research Centers. Trainees are provided an opportunity to learn from the collective expertise of the faculty in the areas of hormone action, regulation of gene expression, adipocyte biology, animal physiology, sophisticated transgenic and gene targeting approaches to endocrine and metabolic disorders, neuroanatomy and neurophysiology, research in human subjects, and strategies for novel treatment modalities. Our trainees have an outstanding record of obtaining independent funding and promotion to faculty positions. These funded investigators now participate in the training of fellows in this and other Programs in Endocrinology, Diabetes and Metabolism. Since the last competitive renewal of this grant, the Division has added new, talented faculty and expanded its research space and core facilities. In particular, the program is strongly supported by core facilities at Beth Israel Deaconess Medical Center in Genomics, Proteomics, Metabolomics, Mass Spectrometry, Flow Cytometry, Biostatistics and Bioinformatics, and Transgenic mouse generation. The program has further formalized its curriculum in the Responsible Conduct of Research. The success of the trainees reflects the outstanding quality of this Endocrine Training Program.