Spectral and Temporal Integration in the Auditory System

我们的长期目标是阐明神经活动、声音处理、知觉 和行为。我们特别建议建立神经活动与辨别和 检测非人类受试者初级听觉皮质(A1)和侧带的声音特征 当听觉大脑皮层层级提升时，狂欢转变的目标。我们 回答问题：听觉皮质的神经元反应如何与非人类受试者的 在检测声音调制存在时的心理物理和行为表现？三位一体 AIMS旨在比较A1和两侧与这些问题相关的三个基本方面 听觉皮质的带状区域，以确定沿上升方向处理的侧重点的变化 大脑皮层通路。目的1是确定调制检测的神经基础。目标2是确定 听觉皮质的神经元反应如何与知觉和行为选择相关。目标3是 确定行为状态和任务投入对神经元声音编码能力的影响 功能。为了实现这些目标，我们将建立单个单位之间的数量关系 听觉皮质活动以及神经元和非人类受试者辨别声音的能力，以及 确定哪些代码最有可能构成感知能力的基础。我们也将从单个单元进行记录，而 非人受试者辨别声音以确定初级和次级感觉皮层的作用 从感觉到任务表现转变的领域。这将让我们深入了解 参与一项任务提高了单个神经元水平的神经处理能力，以及是否主要 感觉皮质接收信息或参与导致行动的过程。因为 该建议将大脑功能与大脑的不同部分联系起来，这与更好地理解 像中风这样的脑损伤是如何影响听觉功能的。这些研究的结果 研究将帮助我们更好地理解注意声音如何调节听觉活动，从而使 这项基础科学与谱系障碍相关(包括但不限于注意力 缺陷障碍、阅读障碍等)。这一结果也可能有助于指导 助听器和人工耳蜗的编码，因为神经编码和专注于声音的能力 都与设计这些设备有关。

Our long-term goal is to elucidate the relationship between neural activity, sound processing, perception and behavior. We specifically propose to establish the relationship of neural activity to discriminating and detecting sound features in the primary auditory cortex (A1) and lateral belt of non-human subjects with the goal of reveling the transformations occurring as the auditory cortical hierarchy is ascended. We address the question: How do neuronal responses in auditory cortex relate to non-human subjects' psychophysical and behavioral performance in detecting the presence of sound modulation? The three aims are designed to compare three fundamental aspects related to these issues in A1 and in two lateral belt areas of auditory cortex to determine the changing emphasis of processing along the ascending cortical pathway. Aim 1 is to determine the neural basis of modulation detection. Aim 2 is to determine how neuron responses from auditory cortex are related to perception and behavioral choices. Aim 3 is to determine the effect of behavioral state and task-engagement on neurons ability to encode sound features. To achieve these aims, we will establish the quantitative relationships between single unit auditory cortical activity and the ability of neurons and non-human subjects to discriminate sounds, and determine what codes most likely underlie perceptual ability. We will also record from single units while non-human subjects discriminate sound to determine the role of primary and secondary sensory cortical areas in the transformation from sensation to task performance. This will give insight into how active engagement in a task improves neural processing ability at the single neuron level and whether primary sensory cortex receives information or is involved in the processes that lead to action. Because the proposal relates brain function to different parts of the brain it is relevant for a better understanding about how punctate brain damage such as that cause by stroke affects auditory function. The results of these studies will help us to better understand how attending sound modulates auditory activity and thus makes this basic science have relevance for the spectrum disorders (that include, but are not limited to attention deficit disorder, dyslexia, etc). The results also could have relevance in helping to guide approaches to coding for hearing aids and cochlear implants since both neural coding and the ability to focus on sounds are relevant for designing these devices.