FREQUENCY INTEGRATION IN THE AUDITORY CORTEX

描述：（改编自申请人的摘要）：这项工作的目标是 阐明听觉皮层神经活动与声音的关系 perception.申请人将确定1）人类的能力， 非人类灵长类动物感知和整合光谱和时间特征的能力 听皮层单个神经元反应的关系 到心理生理表现。对于目标1，人类和非人类受试者将被 被训练来辨别沿沿着时间或频谱维度变化的声音， 对于目标2，将记录非人灵长类动物听觉皮层中的神经元 在行为歧视中。信号检测方法将用于 确定单个神经元的辨别能力，以及它们是否 发射与声音的物理属性或 更高级别的决策来响应声音。数据将提供 了解皮质破坏的影响，以及 对时间声学处理有基本的了解。该结果属 用于治疗中风和阅读障碍的潜在用途。

DESCRIPTION: (Adapted from applicant's abstract): The goal of this work is to elucidate the relationship between neural activity in auditory cortex and sound perception. The applicant will determine 1) the abilities of humans and nonhuman primates to perceive and integrate spectral and temporal features of sounds, and 2) the relationship of single neuron responses in auditory cortex to psychophysical performance. For Aim 1, human and nonhuman subjects will be trained to discriminate sounds that vary along temporal or spectral dimensions, and for Aim 2, neurons will be recorded in nonhuman primate auditory cortex during behavioral discriminations. Signal detection methods will be used to determine the discriminative capabilities of single neurons, and whether their firing is more closely associated with the physical attributes of sound or the higher level decision to respond to the sound. The data will provide information for understanding the effects of cortical disruptions, as well as basic understanding of temporal acoustic processing. The results are of potential use for treating stroke and dyslexia.