FREQUENCY INTEGRATION IN THE AUDITORY CORTEX

听觉皮层的频率整合

• 批准号: 6497856
• 负责人: MITCHELL L SUTTER
• 金额: $ 22.92万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6497856
• 关键词: Primates; auditory cortex; auditory discrimination; auditory stimulus; auditory threshold; behavioral /social science research tag; hearing; human subject; loudness; neural facilitation; neural information processing; neural inhibition; neuroanatomy; neurons; neuropsychology; performance; psychoacoustics; sound frequency; sound perception

DESCRIPTION: (Adapted from applicant's abstract): The goal of this work is to elucidate the relationship between neural activity in auditory cortex and sound perception. The applicant will determine 1) the abilities of humans and nonhuman primates to perceive and integrate spectral and temporal features of sounds, and 2) the relationship of single neuron responses in auditory cortex to psychophysical performance. For Aim 1, human and nonhuman subjects will be trained to discriminate sounds that vary along temporal or spectral dimensions, and for Aim 2, neurons will be recorded in nonhuman primate auditory cortex during behavioral discriminations. Signal detection methods will be used to determine the discriminative capabilities of single neurons, and whether their firing is more closely associated with the physical attributes of sound or the higher level decision to respond to the sound. The data will provide information for understanding the effects of cortical disruptions, as well as basic understanding of temporal acoustic processing. The results are of potential use for treating stroke and dyslexia.

描述：（改编自申请人的摘要）：这项工作的目标是 阐明听觉皮层神经活动与声音之间的关系 洞察力。申请人将确定 1) 人类的能力和 非人类灵长类动物感知并整合光谱和时间特征 声音，2) 听觉皮层单个神经元反应的关系 到心理物理表现。对于目标 1，人类和非人类受试者将 训练以区分沿时间或频谱维度变化的声音， 对于目标 2，将在非人类灵长类动物听觉皮层中记录神经元 在行为歧视期间。信号检测方法将用于 确定单个神经元的辨别能力，以及它们是否 射击与声音或物体的物理属性更密切相关。 高层决定对声音做出反应。数据将提供 用于了解皮质破坏的影响的信息，以及 对时间声学处理的基本了解。结果是 潜在用于治疗中风和阅读障碍。