Psychotherapy Research Center: SOBC Admin Supplement: Targeting self-regulatory deficits through cognitive remediation intervention

整体 摘要 我们寻求更新我们的心理治疗发展研究中心（PDC）致力于发展， 评估和传播有效的治疗方法，并围绕行为的阶段模型组织 治疗发展（Rounsaville，卡罗尔和Onken，2001）。该中心的目标是（1）加速 通过转化方法发展行为疗法的进展;（2）提供 模型和资源的治疗开发工作在其他设置。通过强调科学 行为研究的进展，我们的目标是促进发展和有效实施 最有效的行为干预措施，并了解他们如何发挥其作用， 成瘾的过程。PDC由一个研究/行政核心组成，致力于科学研究， 协调、向组成项目提供集中服务、支持第一阶段试点项目， 培训新的调查员和技术转让，以及三个单独的组成部分。在续约期间 在此期间，核心工作人员将监督一个雄心勃勃的试点研究计划，并提供科学监督，管理， 一组核心评估和技术援助，以沿着协商和 协助其他研究中心的研究者和临床医生。三个组成部分将评估1：认知 控制训练，以提高CBT 4CBT，2。通过适应性善后护理扩大治疗效果 干预; 3.评估短期训练对渴求的调节作用及其神经机制 我们仍然是NIDA唯一致力于开发，测试和传播行为疗法的中心。 在过去4年的支持中，我们成功地实现了我们3个组成项目的具体目标， 开展了12个试点项目，出版了近400份出版物。我们作为一个地方，国家， 提供戒毒治疗方面的国际资源，为88名受训人员提供研究培训和指导， 初级教师，以及培训循证疗法，以数千名临床医生。我们带来了两个 这些疗法起源于中心试点，低成本强化干预和计算机化 认知行为疗法（CBT 4CBT），他们被广泛认为是经验验证的点 治疗并在大型服务提供系统中实施。我们培养了多种 青少年吸烟治疗的独立卫星计划，基于技术的干预措施，培训 研究和传播以及减少吸毒人群中的艾滋病毒危险行为。我们整合 神经影像学的组成部分试验，产生了丰富的数据，神经相关的治疗结果， 有效的治疗如何改变神经生物学过程。我们已经广泛提供了这些数据 通过建立神经信息学数据库和知识库。

Overall ABSTRACT We seek to renew our Psychotherapy Development Research Center (PDC) dedicated to the development, evaluation and dissemination of effective therapies and organized around the Stage Model of behavioral therapies development (Rounsaville, Carroll & Onken, 2001). The goals of this Center are to (1) accelerate progress in the development of behavioral therapies through a translational approach and (2) to provide a model and resource for therapy development efforts in other settings. By emphasizing the scientific progression of behavioral research, our aims are to foster development and effective implementation of the most potent behavioral interventions possible and to understand how they exert their effects by targeting core processes of addiction. The PDC consists of a Research/Administrative Core devoted to scientific coordination, provision of centralized services to component projects, support for pilot Stage I level projects, training of new investigators and technology transfer, and three individual components. During the renewal period, core staff will oversee an ambitious pilot study program and provide scientific oversight, administration, a core battery of assessments, and technical assistance to center projects along with consultation and assistance to investigators and clinicians at other sites. The three components will evaluate 1: Cognitive control training to enhance CBT4CBT, 2. Extending treatment effects through an adaptive aftercare intervention, and 3, evaluating brief training in regulation of craving and its neural mechanisms We remain NIDA's only Center dedicated to the developing, testing, and dissemination of behavioral therapies. In the past 4 years of support, we have successfully met the Specific Aims of our 3 component projects, conducted 12 pilot projects, and generated almost 400 publications. We have served as a local, national, and international resource on addiction treatment, providing research training and mentoring to 88 trainees and junior faculty, as well as training in evidence based therapies to thousands of clinicians. We have brought two therapies which had their origins as Center pilots, low cost reinforcement interventions and computerized cognitive behavioral therapy (CBT4CBT) to the point where they are widely recognized as empirically validated treatments and implemented in large service delivery systems. We have fostered the development of multiple independent satellite programs in treatment of adolescent smoking, technology based interventions, training studies and dissemination and reducing HIV risk behaviors in drug using populations. We have integrated neuroimaging into component trials, yielding a wealth of data on neural correlates of treatment outcome and how effective treatments may change neurobiological processes. We have made these data widely available through establishing a neuroinformatics database and repository.