Integrative Program in Complex Biological System (ipCBS)

描述（由申请人提供）：这是复杂生物系统综合项目（ipCBS）的更新申请，这是一个研究生培训项目，为生物物理学和生物信息学组的学生提供专业化。ipCBS是一个综合性的跨学科项目，专门围绕复杂生物系统（“系统生物学”）的理解和工程设计。在基本层面上，该计划旨在解决与培养科学家同时精通生物学，数学，物理学和工程学的多种语言相关的社会学和语言学问题。这个程序建立在一个全新的基础上，专注于观察、建模和复杂系统的操作。在过去的赠款期间，ipCBS继续开发和发展课程，特别是在基于实践项目的体验式学习领域。因此，作为该培训计划的直接成果，专门建造了一个研究生教学实验室，并以冷泉港/伍兹霍尔的精神进行了一对必修课程“动力系统”，这已成为研究生第一年经验的关键。ipCBS的要点如下：长期目标：为以团队为基础的生物医学科学和人类健康跨学科方法驱动的研究环境提供必要的关键培训，并以大规模和高度复杂的数据为主导。方法：ipCBS将四项核心原则作为研究生培训的基础。1)关注生物组织的基本原理，从分子到细胞水平。2)从跨学科团队的角度关注复杂系统。3)专注于打破语言/社会学障碍。4)注重指导。

DESCRIPTION (provided by applicant): This is an application for renewal of the Integrative Program in Complex Biological Systems (ipCBS), a graduate training program providing a specialization for students that are members of the Biophysics and Bioinformatics group. The ipCBS is a comprehensive interdisciplinary program specifically designed around the understanding and engineering of complex biological systems ("systems biology"). At a fundamental level, this program seeks to solve the sociological and linguistic problems associated with training scientists to be simultaneously conversant in the multiple languages of biology, mathematics, physics, and engineering. This program was built on an entirely new foundation focused on observation, modeling, and manipulation of complex systems. Over the past grant period, the ipCBS has continued to develop and evolve the curriculum, especially in the area of hands-on project based, experiential learning. As a result, a purpose-built Graduate Teaching Laboratory was constructed as a direct outcome of this training program, and a pair of required courses "Dynamical Systems," conducted in the spirit of Cold Spring Harbor / Woods Hole, have become a keystone of the graduate first year experience. The key points of the ipCBS are as follows: Long term objective: To provide critical training necessary for a research environment driven by team-based interdisciplinary approaches to biomedical science and human health and dominated by large-scale and high complexity data. Approach: The ipCBS holds four core principles as the basis for graduate training. 1) Focus on the basic principles of biological organization, from the molecular to the cellular level. 2) Focus on complex systems from an interdisciplinary team-based perspective. 3) Focus on breaking down the language/sociology barrier. 4) Focus on mentoring.